Gasdermins deliver a deadly punch to cancer

Cheng Shen; Abhimanu Pandey; Si Ming Man

doi:10.1038/s41422-020-0316-7

Gasdermins deliver a deadly punch to cancer

Cheng Shen, Abhimanu Pandey, Si Ming Man^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer immunotherapy.

Original language	English
Pages (from-to)	463-464
Number of pages	2
Journal	Cell Research
Volume	30
Issue number	6
DOIs	https://doi.org/10.1038/s41422-020-0316-7
Publication status	Published - 1 Jun 2020

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title = "Gasdermins deliver a deadly punch to cancer",

abstract = "The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer immunotherapy.",

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AB - The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer immunotherapy.

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JO - Cell Research

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Gasdermins deliver a deadly punch to cancer

Abstract

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