Gasdermins deliver a deadly punch to cancer

Cheng Shen, Abhimanu Pandey, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    The pore-forming gasdermin proteins mediate a lytic and proinflammatory form of cell death called pyroptosis and have been linked to the host defense against infection. Two recent studies published in Nature revealed that induction of pyroptosis in tumor cells promotes anti-tumor activity, highlighting gasdermins as potential new targets in cancer immunotherapy.
    Original languageEnglish
    Pages (from-to)463-464
    Number of pages2
    JournalCell Research
    Volume30
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2020

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