Genome-wide ENU mutagenesis to reveal immune regulators

Keats A. Nelms*, Christopher C. Goodnow

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    112 Citations (Scopus)

    Abstract

    A complete list of molecular components for immune system function is now available with the completion of the human and mouse genome sequences. However, identification and functional annotation of genes involved in immunological processes require a discovery methodology that can efficiently and broadly analyze the complex interplay of these components in vivo. Our recent experience indicates that genome-wide chemical mutagenesis in the mouse is an extremely powerful methodology for the identification of genes required for complex immunological processes.

    Original languageEnglish
    Pages (from-to)409-418
    Number of pages10
    JournalImmunity
    Volume15
    Issue number3
    DOIs
    Publication statusPublished - 2001

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