@article{059e1747fd9445e4a69a1af1fa553217,
title = "Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma",
abstract = "Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously associated with CMM risk reached genome-wide significance (P < 5 × 10-8), as did 2 previously reported but unreplicated loci and all 13 established loci. Newly associated SNPs fall within putative melanocyte regulatory elements, and bioinformatic and expression quantitative trait locus (eQTL) data highlight candidate genes in the associated regions, including one involved in telomere biology.",
author = "Law, {Matthew H.} and Bishop, {D. Timothy} and Lee, {Jeffrey E.} and Myriam Brossard and Martin, {Nicholas G.} and Moses, {Eric K.} and Fengju Song and Barrett, {Jennifer H.} and Rajiv Kumar and Easton, {Douglas F.} and Pharoah, {Paul D.P.} and Swerdlow, {Anthony J.} and Kypreou, {Katerina P.} and Taylor, {John C.} and Mark Harland and Juliette Randerson-Moor and Akslen, {Lars A.} and Andresen, {Per A.} and Avril, {Marie Fran{\c c}oise} and Esther Azizi and Scarr{\`a}, {Giovanna Bianchi} and Brown, {Kevin M.} and Tadeusz D{\c e}bniak and Duffy, {David L.} and Elder, {David E.} and Shenying Fang and Eitan Friedman and Pilar Galan and Paola Ghiorzo and Gillanders, {Elizabeth M.} and Goldstein, {Alisa M.} and Gruis, {Nelleke A.} and Johan Hansson and Per Helsing and Marko Ho{\v c}evar and Veronica H{\"o}iom and Christian Ingvar and Kanetsky, {Peter A.} and Chen, {Wei V.} and Landi, {Maria Teresa} and Julie Lang and Lathrop, {G. Mark} and Jan Lubi{\'n}ski and MacKie, {Rona M.} and Mann, {Graham J.} and Anders Molven and Montgomery, {Grant W.} and Srdjan Novakovi{\'c} and H{\aa}kan Olsson and Susana Puig",
note = "Publisher Copyright: {\textcopyright} 2015 Nature America, Inc. All rights reserved.",
year = "2015",
month = aug,
day = "27",
doi = "10.1038/ng.3373",
language = "English",
volume = "47",
pages = "987--995",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "9",
}