@article{7deaab5114a042559941794d4a2f6a88,
title = "Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene",
abstract = "The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and BCL6-corepressor gene Bcor. Moreover, we find unexpected concomitant multigenic lesions involving Cdkn2a loss and other cancer genes including Nras, Kras and Bcor. These findings challenge the assumed two-hit model of Eμ-Myc lymphoma and demonstrate a functional in vivo role for Bcor in suppressing tumorigenesis.",
author = "Marcus Lefebure and Tothill, {Richard W.} and Elizabeth Kruse and Hawkins, {Edwin D.} and Jake Shortt and Matthews, {Geoffrey M.} and Gregory, {Gareth P.} and Martin, {Benjamin P.} and Kelly, {Madison J.} and Izabela Todorovski and Doyle, {Maria A.} and Richard Lupat and Jason Li and Jan Schroeder and Meaghan Wall and Stuart Craig and Gretchen Poortinga and Don Cameron and Megan Bywater and Lev Kats and Gearhart, {Micah D.} and Bardwell, {Vivian J.} and Dickins, {Ross A.} and Hannan, {Ross D.} and Papenfuss, {Anthony T.} and Johnstone, {Ricky W.}",
note = "Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = mar,
day = "6",
doi = "10.1038/ncomms14581",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
}