TY - JOUR
T1 - Genomic structure of human GST omega 1
AU - Whitbread, Astrid K.
AU - Coggan, Marjorie
AU - Board, Philip G.
PY - 2001/2/28
Y1 - 2001/2/28
N2 - The omega class glutathione transferases is the most recently identified class of GSTs. Omega GSTs have several unique features, including a conserved cysteine residue in the active site, and a unique N-terminal extension. Some members of the omega class have been shown to exhibit low dehydroascorbate reductase and thioltransferase activities, which are characteristic of the glutaredoxins. Where studied, the omega enzymes have shown low activity towards CDNB, and negligible activities towards other common GST substrates. In this study, the genomic structure of hGST01 was determined. The gene comprises six exons, and spans at least 12.5 kb on human chromosome 10.
AB - The omega class glutathione transferases is the most recently identified class of GSTs. Omega GSTs have several unique features, including a conserved cysteine residue in the active site, and a unique N-terminal extension. Some members of the omega class have been shown to exhibit low dehydroascorbate reductase and thioltransferase activities, which are characteristic of the glutaredoxins. Where studied, the omega enzymes have shown low activity towards CDNB, and negligible activities towards other common GST substrates. In this study, the genomic structure of hGST01 was determined. The gene comprises six exons, and spans at least 12.5 kb on human chromosome 10.
KW - Dehydroascorbate reductase
KW - Glutathione transferase
KW - Omega class
KW - Thioltransferase
UR - http://www.scopus.com/inward/record.url?scp=0041079499&partnerID=8YFLogxK
M3 - Article
SN - 0009-2797
VL - 133
SP - 331
EP - 333
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 1-3
ER -