Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease

Marco Di Fruscio; Catherine A. Gilchrist; Rohan T. Baker; Douglas A. Gray

doi:10.1016/S0167-4781(98)00035-9

Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease

Marco Di Fruscio, Catherine A. Gilchrist, Rohan T. Baker, Douglas A. Gray^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1398
Issue number	1
DOIs	https://doi.org/10.1016/S0167-4781(98)00035-9
Publication status	Published - 29 May 1998

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title = "Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease",

abstract = "The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.",

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T1 - Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease

AU - Di Fruscio, Marco

AU - Gilchrist, Catherine A.

AU - Baker, Rohan T.

AU - Gray, Douglas A.

PY - 1998/5/29

Y1 - 1998/5/29

N2 - The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.

AB - The murine Unp gene encodes a ubiquitin-specific protease, a member of a family of enzymes that includes the product of the human tre-2 oncogene. The Unp gene has previously been mapped to chromosome 9. We have cloned in bacteriophage a 50 kilobase region of chromosome 9 containing the Unp gene, and have determined the nucleotide sequence of the gene. The gene has 22 exons, distributed over 47.4 kb. A processed ribosomal S2 pseudogene was identified in the third intron of the Unp gene. Expression of Unp is driven by a GC-rich, 'housekeeping' type promoter.

KW - Protease

KW - Ubiquitin

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DO - 10.1016/S0167-4781(98)00035-9

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EP - 17

JO - Biochimica et Biophysica Acta - Gene Structure and Expression

JF - Biochimica et Biophysica Acta - Gene Structure and Expression

IS - 1

ER -

Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease

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