Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

Kate S. Campbell; Amalanie J. Foster; Carolyn T. Dillon; Margaret M. Harding

doi:10.1016/j.jinorgbio.2006.01.034

Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

Kate S. Campbell, Amalanie J. Foster, Carolyn T. Dillon^*, Margaret M. Harding

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

The cytotoxic effects of molybdocene dichloride (Cp₂MoCl₂) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp₂MoCl₂ produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp₂MoCl₂. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp₂MoCl₂ (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.

Original language	English
Pages (from-to)	1194-1198
Number of pages	5
Journal	Journal of Inorganic Biochemistry
Volume	100
Issue number	7
DOIs	https://doi.org/10.1016/j.jinorgbio.2006.01.034
Publication status	Published - Jul 2006
Externally published	Yes

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10.1016/j.jinorgbio.2006.01.034

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@article{5eefcda2bb674d9dad8a0f05f6a79ffa,

title = "Genotoxicity and transmission electron microscopy studies of molybdocene dichloride",

abstract = "The cytotoxic effects of molybdocene dichloride (Cp2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.",

keywords = "Antitumor metallocene, Genotoxicity, Micronucleus assay, Molybdocene dichloride, TEM",

author = "Campbell, {Kate S.} and Foster, {Amalanie J.} and Dillon, {Carolyn T.} and Harding, {Margaret M.}",

year = "2006",

month = jul,

doi = "10.1016/j.jinorgbio.2006.01.034",

language = "English",

volume = "100",

pages = "1194--1198",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "7",

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TY - JOUR

T1 - Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

AU - Campbell, Kate S.

AU - Foster, Amalanie J.

AU - Dillon, Carolyn T.

AU - Harding, Margaret M.

PY - 2006/7

Y1 - 2006/7

N2 - The cytotoxic effects of molybdocene dichloride (Cp2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.

AB - The cytotoxic effects of molybdocene dichloride (Cp2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per μM of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 μM) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed.

KW - Antitumor metallocene

KW - Genotoxicity

KW - Micronucleus assay

KW - Molybdocene dichloride

KW - TEM

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U2 - 10.1016/j.jinorgbio.2006.01.034

DO - 10.1016/j.jinorgbio.2006.01.034

M3 - Article

SN - 0162-0134

VL - 100

SP - 1194

EP - 1198

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 7

ER -

Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

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