Germinal Center Lymphocyte Ratios and Successful HIV Vaccines

Paula Gonzalez-Figueroa; Jonathan A. Roco; Carola G. Vinuesa

doi:10.1016/j.molmed.2016.12.009

Germinal Center Lymphocyte Ratios and Successful HIV Vaccines

Paula Gonzalez-Figueroa, Jonathan A. Roco, Carola G. Vinuesa^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

6 Citations (Scopus)

Abstract

Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (T_FH) lymphocytes.

Original language	English
Pages (from-to)	95-97
Number of pages	3
Journal	Trends in Molecular Medicine
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.molmed.2016.12.009
Publication status	Published - 1 Feb 2017

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10.1016/j.molmed.2016.12.009

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title = "Germinal Center Lymphocyte Ratios and Successful HIV Vaccines",

abstract = "Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.",

author = "Paula Gonzalez-Figueroa and Roco, {Jonathan A.} and Vinuesa, {Carola G.}",

note = "Publisher Copyright: {\textcopyright} 2016",

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AU - Gonzalez-Figueroa, Paula

AU - Roco, Jonathan A.

AU - Vinuesa, Carola G.

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N2 - Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.

AB - Current HIV vaccines are poor inducers of neutralizing antibodies (nAbs). A recent study in Cell Reports used serial fine-needle aspirates from rhesus macaque lymph nodes following HIV-1 surface envelope glycoprotein (Env) trimer immunization, generating a substantial production of HIV-1 nAbs. A remarkable correlation was found between antibody titers and a high frequency and ratio of germinal center B and T follicular helper (TFH) lymphocytes.

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U2 - 10.1016/j.molmed.2016.12.009

DO - 10.1016/j.molmed.2016.12.009

M3 - Short survey

SN - 1471-4914

VL - 23

SP - 95

EP - 97

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

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Germinal Center Lymphocyte Ratios and Successful HIV Vaccines

Abstract

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