Glucocorticoid-induced hypertension: From mouse to man

Judith A. Whitworth, Christopher G. Schyvens, Yi Zhang, George J. Mangos, John J. Kelly

    Research output: Contribution to journalArticlepeer-review

    57 Citations (Scopus)


    1. Adrenocorticotrophic hormone (ACTH) raises blood pressure in humans, sheep, rat and mouse. In rat and humans, but not sheep, the hypertension can be explained by glucocorticoid excess. 2. In both rat and humans, the hypertension is associated with a rise in cardiac output and renal vascular resistance. 3. In both rat and humans, the nitric oxide system is implicated in glucocorticoid hypertension. 4. In both rat and humans, hypertension due to naturally occurring glucocorticoids is not prevented by drugs that block classical glucocorticoid or mineralocorticoid receptors. 5. Abnormalities in glucocorticoid metabolism may contribute to some forms of 'essential' hypertension.

    Original languageEnglish
    Pages (from-to)993-996
    Number of pages4
    JournalClinical and Experimental Pharmacology and Physiology
    Issue number12
    Publication statusPublished - 2001


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