Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

Dianne E. Bamber; Philip G. Board; Marjorie Coggan; James B. Elder; Mark Deakin; Ramesh Rajagopal; A. Sergei Fawole; Richard C. Strange; Anthony A. Fryer

Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

Dianne E. Bamber^*, Philip G. Board, Marjorie Coggan, James B. Elder, Mark Deakin, Ramesh Rajagopal, A. Sergei Fawole, Richard C. Strange, Anthony A. Fryer

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.

Original language	English
Pages (from-to)	98-99
Number of pages	2
Journal	Chemico-Biological Interactions
Volume	133
Issue number	1-3
Publication status	Published - 28 Feb 2001

Cite this

@article{b35327f049cf4d7f8904b510233d6550,

title = "Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer",

abstract = "We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Duke{\'i}s stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.",

keywords = "Colorectal cancer, Duke's stage, GSTT2, Polymorphism",

author = "Bamber, {Dianne E.} and Board, {Philip G.} and Marjorie Coggan and Elder, {James B.} and Mark Deakin and Ramesh Rajagopal and Fawole, {A. Sergei} and Strange, {Richard C.} and Fryer, {Anthony A.}",

year = "2001",

month = feb,

day = "28",

language = "English",

volume = "133",

pages = "98--99",

journal = "Chemico-Biological Interactions",

issn = "0009-2797",

publisher = "Elsevier Ireland Ltd",

number = "1-3",

}

TY - JOUR

T1 - Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

AU - Bamber, Dianne E.

AU - Board, Philip G.

AU - Coggan, Marjorie

AU - Elder, James B.

AU - Deakin, Mark

AU - Rajagopal, Ramesh

AU - Fawole, A. Sergei

AU - Strange, Richard C.

AU - Fryer, Anthony A.

PY - 2001/2/28

Y1 - 2001/2/28

N2 - We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.

AB - We have developed polymerase chain reaction (PCR) based assays to examine 3 polymorphisms in GSTT2 in patients with colorectal cancer. Our results suggest that two of the sites are in linkage disequilibrium with each other and with GSTT1 genotype. Clinical parameters such as Duke's stage, differentiation, tumour location, survival, family history and presence of nodes were also investigated. We identified significant associations between GSTT2 polymorphisms and Dukeís stage. This preliminary data suggests that polymorphism at GSTT2 may be significant in determining outcome in colorectal cancer.

KW - Colorectal cancer

KW - Duke's stage

KW - GSTT2

KW - Polymorphism

UR - http://www.scopus.com/inward/record.url?scp=0003129133&partnerID=8YFLogxK

M3 - Article

SN - 0009-2797

VL - 133

SP - 98

EP - 99

JO - Chemico-Biological Interactions

JF - Chemico-Biological Interactions

IS - 1-3

ER -

Glutathione S-transferase GSTT2 polymorphism and outcome in patients with colorectal cancer

Abstract

Other files and links

Fingerprint

Cite this