Glycoprotein Ib-IX-V

R. K. Andrews; E. E. Gardiner; Y. Shen; J. C. Whisstock; M. C. Berndt

doi:10.1016/S1357-2725(02)00280-7

Glycoprotein Ib-IX-V

R. K. Andrews^*, E. E. Gardiner, Y. Shen, J. C. Whisstock, M. C. Berndt

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

185 Citations (Scopus)

Abstract

Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, αMβ2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include α-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.

Original language	English
Pages (from-to)	1170-1174
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	35
Issue number	8
DOIs	https://doi.org/10.1016/S1357-2725(02)00280-7
Publication status	Published - 1 Aug 2003
Externally published	Yes

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title = "Glycoprotein Ib-IX-V",

abstract = "Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, αMβ2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include α-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.",

keywords = "Glycoprotein Ib-IX-V, Platelets, Thrombosis, Von Willebrand factor",

author = "Andrews, {R. K.} and Gardiner, {E. E.} and Y. Shen and Whisstock, {J. C.} and Berndt, {M. C.}",

year = "2003",

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doi = "10.1016/S1357-2725(02)00280-7",

language = "English",

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TY - JOUR

T1 - Glycoprotein Ib-IX-V

AU - Andrews, R. K.

AU - Gardiner, E. E.

AU - Shen, Y.

AU - Whisstock, J. C.

AU - Berndt, M. C.

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, αMβ2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include α-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.

AB - Glycoprotein (GP) Ib-IX-V is a remarkable platelet adhesion receptor of the leucine-rich repeat family. It has evolved to fulfil its major function of initiating platelet aggregation (thrombus formation) at high-shear stress in flowing blood. In addition to binding von Willebrand factor (vWF) in subendothelial matrix or plasma to trigger platelet aggregation, GPIb-IX-V also binds counter-receptors, αMβ2 (Mac-1) on neutrophils or P-selectin on activated platelets or endothelial cells. GPIb-IX-V ligands also include α-thrombin, clotting factors XI/XIIa, and high-molecular-weight kininogen. Interactions involving GPIb-IX-V are therefore central to vascular processes of thrombosis and inflammation, and the receptor is under intense scrutiny as a potential therapeutic target.

KW - Glycoprotein Ib-IX-V

KW - Platelets

KW - Thrombosis

KW - Von Willebrand factor

UR - http://www.scopus.com/inward/record.url?scp=0038363984&partnerID=8YFLogxK

U2 - 10.1016/S1357-2725(02)00280-7

DO - 10.1016/S1357-2725(02)00280-7

M3 - Short survey

SN - 1357-2725

VL - 35

SP - 1170

EP - 1174

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

IS - 8

ER -

Glycoprotein Ib-IX-V

Abstract

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