TY - JOUR
T1 - Growing up on the streets
T2 - Why B-cell development differs from T-cell development
AU - Townsend, Sarah E.
AU - Weintraub, Bennett C.
AU - Goodnow, Christopher C.
PY - 1999/5/1
Y1 - 1999/5/1
N2 - B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.
AB - B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.
UR - http://www.scopus.com/inward/record.url?scp=0033135089&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(98)01440-6
DO - 10.1016/S0167-5699(98)01440-6
M3 - Comment/debate
SN - 0167-5699
VL - 20
SP - 217
EP - 220
JO - Immunology Today
JF - Immunology Today
IS - 5
ER -