Growing up on the streets: Why B-cell development differs from T-cell development

Sarah E. Townsend; Bennett C. Weintraub; Christopher C. Goodnow

doi:10.1016/S0167-5699(98)01440-6

Growing up on the streets: Why B-cell development differs from T-cell development

Sarah E. Townsend^*, Bennett C. Weintraub, Christopher C. Goodnow

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

32 Citations (Scopus)

Abstract

B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

Original language	English
Pages (from-to)	217-220
Number of pages	4
Journal	Immunology Today
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/S0167-5699(98)01440-6
Publication status	Published - 1 May 1999

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title = "Growing up on the streets: Why B-cell development differs from T-cell development",

abstract = "B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.",

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AU - Goodnow, Christopher C.

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N2 - B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

AB - B-cell development differs significantly from T-cell development in that negative selection of autoreactive B cells can occur in the same microenvironment in which productive immune responses begin. Here, Sarah Townsend and colleagues discuss how this 'growing up on the streets' might provide a mechanism that fills holes in the B-cell repertoire, much as major histocompatibility complex polymorphism fills holes in the T-cell repertoire.

UR - https://www.scopus.com/pages/publications/0033135089

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DO - 10.1016/S0167-5699(98)01440-6

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Growing up on the streets: Why B-cell development differs from T-cell development

Abstract

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