Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions

Max Kirkby, Daniel Enosi Tuipulotu, Shouya Feng, Jordan Lo Pilato, Si Ming Man*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    3 Citations (Scopus)

    Abstract

    Guanylate-binding proteins (GBPs) are a family of intracellular proteins which have diverse biological functions, including pathogen sensing and host defense against infectious disease. These proteins are expressed in response to interferon (IFN) stimulation and can localize and target intracellular microbes (e.g., bacteria and viruses) by protein trafficking and membrane binding. These properties contribute to the ability of GBPs to induce inflammasome activation, inflammation, and cell death, and to directly disrupt pathogen membranes. Recent biochemical studies have revealed that human GBP1, GBP2, and GBP3 can directly bind to the lipopolysaccharide (LPS) of Gram-negative bacteria. In this review we discuss emerging data highlighting the functional versatility of GBPs, with a focus on their molecular mechanisms of pattern recognition and antimicrobial activity.

    Original languageEnglish
    Pages (from-to)883-893
    Number of pages11
    JournalTrends in Biochemical Sciences
    Volume48
    Issue number10
    DOIs
    Publication statusPublished - Oct 2023

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