Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition

Peter B. Glover; Peter R. Ashton; Laura J. Childs; Alison Rodger; Michael Kercher; René M. Williams; Luisa De Cola; Zoe Pikramenou

doi:10.1021/ja029886s

Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition

Peter B. Glover, Peter R. Ashton, Laura J. Childs, Alison Rodger, Michael Kercher, René M. Williams, Luisa De Cola, Zoe Pikramenou^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

195 Citations (Scopus)

Abstract

Luminescent Ln-Pt₂ metallohairpin complexes have been developed, and their intercalative recognition with DNA has been demonstrated with linear dichroism spectroscopy. The heterotrimetallic complexes were formed in a one-step reaction, by assembly of an aminopolycarboxylate ligand, a platinum terpyridine unit, and the lanthanide salt. The metallohairpin complexes bear a neutral lanthanide moiety and two positively charged platinum-containing intercalating units. The Nd(III) analogues are luminescent in the near infrared, and this near-IR luminescence is retained upon binding to DNA. The DNA recognition was demonstrated by linear dichroism spectroscopy. The linear dichroism spectra suggested that the complexes bind perpendicular to the DNA helical axis, confirming intercalative recognition accompanied by dramatic stiffening of DNA, which suggests bis-intercalation of the complex.

Original language	English
Pages (from-to)	9918-9919
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	33
DOIs	https://doi.org/10.1021/ja029886s
Publication status	Published - 20 Aug 2003
Externally published	Yes

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title = "Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition",

abstract = "Luminescent Ln-Pt2 metallohairpin complexes have been developed, and their intercalative recognition with DNA has been demonstrated with linear dichroism spectroscopy. The heterotrimetallic complexes were formed in a one-step reaction, by assembly of an aminopolycarboxylate ligand, a platinum terpyridine unit, and the lanthanide salt. The metallohairpin complexes bear a neutral lanthanide moiety and two positively charged platinum-containing intercalating units. The Nd(III) analogues are luminescent in the near infrared, and this near-IR luminescence is retained upon binding to DNA. The DNA recognition was demonstrated by linear dichroism spectroscopy. The linear dichroism spectra suggested that the complexes bind perpendicular to the DNA helical axis, confirming intercalative recognition accompanied by dramatic stiffening of DNA, which suggests bis-intercalation of the complex.",

author = "Glover, {Peter B.} and Ashton, {Peter R.} and Childs, {Laura J.} and Alison Rodger and Michael Kercher and Williams, {Ren{\'e} M.} and {De Cola}, Luisa and Zoe Pikramenou",

year = "2003",

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day = "20",

doi = "10.1021/ja029886s",

language = "English",

volume = "125",

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T1 - Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition

AU - Glover, Peter B.

AU - Ashton, Peter R.

AU - Childs, Laura J.

AU - Rodger, Alison

AU - Kercher, Michael

AU - Williams, René M.

AU - De Cola, Luisa

AU - Pikramenou, Zoe

PY - 2003/8/20

Y1 - 2003/8/20

N2 - Luminescent Ln-Pt2 metallohairpin complexes have been developed, and their intercalative recognition with DNA has been demonstrated with linear dichroism spectroscopy. The heterotrimetallic complexes were formed in a one-step reaction, by assembly of an aminopolycarboxylate ligand, a platinum terpyridine unit, and the lanthanide salt. The metallohairpin complexes bear a neutral lanthanide moiety and two positively charged platinum-containing intercalating units. The Nd(III) analogues are luminescent in the near infrared, and this near-IR luminescence is retained upon binding to DNA. The DNA recognition was demonstrated by linear dichroism spectroscopy. The linear dichroism spectra suggested that the complexes bind perpendicular to the DNA helical axis, confirming intercalative recognition accompanied by dramatic stiffening of DNA, which suggests bis-intercalation of the complex.

AB - Luminescent Ln-Pt2 metallohairpin complexes have been developed, and their intercalative recognition with DNA has been demonstrated with linear dichroism spectroscopy. The heterotrimetallic complexes were formed in a one-step reaction, by assembly of an aminopolycarboxylate ligand, a platinum terpyridine unit, and the lanthanide salt. The metallohairpin complexes bear a neutral lanthanide moiety and two positively charged platinum-containing intercalating units. The Nd(III) analogues are luminescent in the near infrared, and this near-IR luminescence is retained upon binding to DNA. The DNA recognition was demonstrated by linear dichroism spectroscopy. The linear dichroism spectra suggested that the complexes bind perpendicular to the DNA helical axis, confirming intercalative recognition accompanied by dramatic stiffening of DNA, which suggests bis-intercalation of the complex.

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SN - 0002-7863

VL - 125

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EP - 9919

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 33

ER -

Hairpin-shaped heterometallic luminescent lanthanide complexes for DNA intercalative recognition

Abstract

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