Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description

Kerrie Anne Chen; Fabienne Brilot; Russell C. Dale; Antony R. Lafferty; Peter Ian Andrews

doi:10.1016/j.ejpn.2017.06.002

Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description

Kerrie Anne Chen, Fabienne Brilot, Russell C. Dale, Antony R. Lafferty, Peter Ian Andrews^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Purpose To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). Results A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. Conclusion We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.

Original language	English
Pages (from-to)	898-901
Number of pages	4
Journal	European Journal of Paediatric Neurology
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.ejpn.2017.06.002
Publication status	Published - Nov 2017
Externally published	Yes

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10.1016/j.ejpn.2017.06.002

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title = "Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description",

abstract = "Purpose To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). Results A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. Conclusion We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.",

keywords = "Antibody, Hashimoto encephalitis, Myelin oligodendrocyte glycoprotein",

author = "Chen, {Kerrie Anne} and Fabienne Brilot and Dale, {Russell C.} and Lafferty, {Antony R.} and Andrews, {Peter Ian}",

note = "Publisher Copyright: {\textcopyright} 2017 European Paediatric Neurology Society",

year = "2017",

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doi = "10.1016/j.ejpn.2017.06.002",

language = "English",

volume = "21",

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T1 - Hashimoto's encephalopathy and anti-MOG antibody encephalitis

T2 - 50 years after Lord Brain's description

AU - Chen, Kerrie Anne

AU - Brilot, Fabienne

AU - Dale, Russell C.

AU - Lafferty, Antony R.

AU - Andrews, Peter Ian

PY - 2017/11

Y1 - 2017/11

N2 - Purpose To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). Results A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. Conclusion We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.

AB - Purpose To consider the role of anti-MOG Abs associated encephalitis in Hashimoto's Encephalitis (HE). Results A 10 year old girl with pre-existing Hashimoto's thyroiditis presented with dysarthria, ataxia and lethargy whilst euthyroid. Brain MRI showed multifocal T2 and FLAIR hyperintense lesions. She responded promptly to treatment with corticosteroids. Her clinical scenario was comparable to a sizeable minority of patients diagnosed with HE in the literature, who have similar brain MRIs. Serum was positive for anti-myelin oligodendrocyte glycoprotein (MOG) Ab, implicating this antibody-mediated process in this patient's illness. Conclusion We hypothesize that anti-MOG Ab associated demyelination may underlie a subset of patients with HE.

KW - Antibody

KW - Hashimoto encephalitis

KW - Myelin oligodendrocyte glycoprotein

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DO - 10.1016/j.ejpn.2017.06.002

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JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

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ER -

Hashimoto's encephalopathy and anti-MOG antibody encephalitis: 50 years after Lord Brain's description

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