Having your cake and eating it too – a new target for sporozoite-neutralising mAbs

Joe A. Kaczmarski; Colin J. Jackson; Ian A. Cockburn

doi:10.1016/j.pt.2025.02.002

Having your cake and eating it too – a new target for sporozoite-neutralising mAbs

Joe A. Kaczmarski, Colin J. Jackson, Ian A. Cockburn^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

Abstract

Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.

Original language	English
Pages (from-to)	261-263
Number of pages	3
Journal	Trends in Parasitology
Volume	41
Issue number	4
DOIs	https://doi.org/10.1016/j.pt.2025.02.002
Publication status	Published - Apr 2025

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10.1016/j.pt.2025.02.002

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title = "Having your cake and eating it too – a new target for sporozoite-neutralising mAbs",

abstract = "Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.",

keywords = "cryptic epitope, malaria, neutralizing antibodies, Plasmodium falciparum circumsporozoite protein (PfCSP), sporozoite, vaccine design",

author = "Kaczmarski, \{Joe A.\} and Jackson, \{Colin J.\} and Cockburn, \{Ian A.\}",

note = "{\textcopyright} 2025 Elsevier Ltd",

year = "2025",

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doi = "10.1016/j.pt.2025.02.002",

language = "English",

volume = "41",

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T1 - Having your cake and eating it too – a new target for sporozoite-neutralising mAbs

AU - Kaczmarski, Joe A.

AU - Jackson, Colin J.

AU - Cockburn, Ian A.

PY - 2025/4

Y1 - 2025/4

N2 - Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.

AB - Current malaria vaccines provide suboptimal, waning protection. Dacon et al. identify a protective post-translationally modified epitope on Plasmodium sporozoites that is absent from current vaccines. This discovery deepens our understanding of Plasmodium biology and may inform the development of improved vaccines and complementary prophylactic monoclonal antibodies.

KW - cryptic epitope

KW - malaria

KW - neutralizing antibodies

KW - Plasmodium falciparum circumsporozoite protein (PfCSP)

KW - sporozoite

KW - vaccine design

UR - https://www.scopus.com/pages/publications/85219027473

U2 - 10.1016/j.pt.2025.02.002

DO - 10.1016/j.pt.2025.02.002

M3 - Short survey

C2 - 39984355

AN - SCOPUS:85219027473

SN - 1471-4922

VL - 41

SP - 261

EP - 263

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 4

ER -

Having your cake and eating it too – a new target for sporozoite-neutralising mAbs

Abstract

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