Heterotrimetallic Double Cavity Cages: Syntheses and Selective Guest Binding

Lynn S. Lisboa, Dan Preston, C. John McAdam, L. James Wright, Christian G. Hartinger, James D. Crowley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

A strategy for the generation of heterotrimetallic double cavity (DC) cages [PdnPtmL4]6+ (DC1: n=1, m=2; and DC2: n=2, m=1) is reported. The DC cages were generated by combining an inert platinum(II) tetrapyridylaldehyde complex with a suitably substituted pyridylamine and PdII ions. 1H and DOSY nuclear magnetic resonance spectroscopy (NMR) and electrospray ionization mass spectrometry (ESIMS) data were consistent with the formation of the DC architectures. DC1 and DC2 were shown to interact with several different guest molecules. The structure of DC1, which features two identical cavities, binding two 2,6-diaminoanthraquinone (DAQ) guest molecules was determined by single-crystal X-ray crystallography. In addition, DC1 was shown to bind two molecules of 5-fluorouracil (5-FU) in a statistical (non-cooperative) manner. In contrast, DC2, which features two different cage cavities, was found to interact with two different guests, 5-FU and cisplatin, selectively.

Original languageEnglish
Article numbere202201700
JournalAngewandte Chemie - International Edition
Volume61
Issue number18
DOIs
Publication statusPublished - 25 Apr 2022

Fingerprint

Dive into the research topics of 'Heterotrimetallic Double Cavity Cages: Syntheses and Selective Guest Binding'. Together they form a unique fingerprint.

Cite this