Abstract
A highly efficient rhodium(i) and iridium(i) catalysed dihydroalkoxylation reaction of alkyne diols is employed here for the synthesis of spiroketals and a fused bicyclic ketal. The two metal catalysts show differential selectivity and efficiency for either the cyclisation of the 5-exo or 6-endo-membered rings. For the first time, a dual metal (Rh and Ir) catalyst system is effectively utilised for the formation of the 5,6-spiroketals, more efficiently than the single metal catalysts. The two different metals create a dual activation pathway to enhance the 5- and 6-membered ring closure as compared with the equivalent single catalysts.
Original language | English |
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Pages (from-to) | 4062-4069 |
Number of pages | 8 |
Journal | Dalton Transactions |
Volume | 39 |
Issue number | 17 |
DOIs | |
Publication status | Published - 2010 |