Highly sensitive biosensors based on all-dielectric nanoresonators

Nicolò Bontempi; Katie E. Chong; Henry W. Orton; Isabelle Staude; Duk Yong Choi; Ivano Alessandri; Yuri S. Kivshar; Dragomir N. Neshev

doi:10.1039/c6nr07904k

Highly sensitive biosensors based on all-dielectric nanoresonators

Nicolò Bontempi, Katie E. Chong, Henry W. Orton, Isabelle Staude, Duk Yong Choi, Ivano Alessandri, Yuri S. Kivshar, Dragomir N. Neshev^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

145 Citations (Scopus)

Abstract

Biosensing based on nanophotonic structures has shown a great potential for cost-efficient, high-speed and compact personal medical diagnostics. While plasmonic nanosensors offer high sensitivity, their intrinsically restricted resonance quality factors and strong heating due to metal absorption impose severe limitations on real life applications. Here, we demonstrate an all-dielectric sensing platform based on silicon nanodisks with strong optically-induced magnetic resonances, which are able to detect a concentration of streptavidin of as low as 10^-10 M (mol L^-1) or 5 ng mL^-1, thus pushing the current detection limit by at least two orders of magnitudes. Our study suggests a new direction in biosensing based on bio-compatible, non-toxic, robust and low-loss dielectric nanoresonators with potential applications in medicine, including disease diagnosis and drug detection.

Original language	English
Pages (from-to)	4972-4980
Number of pages	9
Journal	Nanoscale
Volume	9
Issue number	15
DOIs	https://doi.org/10.1039/c6nr07904k
Publication status	Published - 21 Apr 2017

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abstract = "Biosensing based on nanophotonic structures has shown a great potential for cost-efficient, high-speed and compact personal medical diagnostics. While plasmonic nanosensors offer high sensitivity, their intrinsically restricted resonance quality factors and strong heating due to metal absorption impose severe limitations on real life applications. Here, we demonstrate an all-dielectric sensing platform based on silicon nanodisks with strong optically-induced magnetic resonances, which are able to detect a concentration of streptavidin of as low as 10-10 M (mol L-1) or 5 ng mL-1, thus pushing the current detection limit by at least two orders of magnitudes. Our study suggests a new direction in biosensing based on bio-compatible, non-toxic, robust and low-loss dielectric nanoresonators with potential applications in medicine, including disease diagnosis and drug detection.",

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AU - Bontempi, Nicolò

AU - Chong, Katie E.

AU - Orton, Henry W.

AU - Staude, Isabelle

AU - Choi, Duk Yong

AU - Alessandri, Ivano

AU - Kivshar, Yuri S.

AU - Neshev, Dragomir N.

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AB - Biosensing based on nanophotonic structures has shown a great potential for cost-efficient, high-speed and compact personal medical diagnostics. While plasmonic nanosensors offer high sensitivity, their intrinsically restricted resonance quality factors and strong heating due to metal absorption impose severe limitations on real life applications. Here, we demonstrate an all-dielectric sensing platform based on silicon nanodisks with strong optically-induced magnetic resonances, which are able to detect a concentration of streptavidin of as low as 10-10 M (mol L-1) or 5 ng mL-1, thus pushing the current detection limit by at least two orders of magnitudes. Our study suggests a new direction in biosensing based on bio-compatible, non-toxic, robust and low-loss dielectric nanoresonators with potential applications in medicine, including disease diagnosis and drug detection.

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Highly sensitive biosensors based on all-dielectric nanoresonators

Abstract

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