Hippocampal sulcal cavities in depression and healthy individuals

Jerome J Maller; Chantal Meslin; Chantal Meslin; Richard H.S. Thomson; Melissa Daigle; Mera S. Barr; Zafiris J. Daskalakis; Paul B. Fitzgerald

doi:10.1016/j.jad.2013.02.039

Hippocampal sulcal cavities in depression and healthy individuals

Jerome J Maller, Chantal Meslin, Chantal Meslin, Richard H.S. Thomson, Melissa Daigle, Mera S. Barr, Zafiris J. Daskalakis, Paul B. Fitzgerald

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: A literature review suggested age and cognitive problems to be related to an increased prevalence of small areas of signal variation within the hippocampus observed on MRI, described as hippocampal sulcal cavities (HSCs; (Maller et al., 2011)). The current study aimed to describe the prevalence of HSCs in patients with treatment-resistant depression (TRD) and healthy controls over a large age-range. Methods: 115 TRD patients and 86 controls underwent MRI brain scanning. Right and left HSCs were rated separately for prevalence and length. Results: HSCs were observed in 73.04%of those with TRD, statistically more prevalent (p=0.001) than amongst controls (51.16%). These findings are consistent with our review (66%prevalence in memory disorders and 47%in healthy controls). Furthermore, HSC presence and length was associated with aging. Limitations: The study was cross-sectional so its implications for aging are tentative. A larger sample scanned longitudinally will allow for more sophisticated statistical methods by which to investigate the relationship between HSCs, aging, and TRD. Conclusions: Although their clinical significance remains uncertain, the results of the current study suggest that HSCs are related with age and those with TRD have more aged brains than their peers. Crown

Original language	English
Pages (from-to)	785-789
Number of pages	5
Journal	Journal of Affective Disorders
Volume	150
Issue number	3
DOIs	https://doi.org/10.1016/j.jad.2013.02.039
Publication status	Published - 2013

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10.1016/j.jad.2013.02.039

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title = "Hippocampal sulcal cavities in depression and healthy individuals",

abstract = "Background: A literature review suggested age and cognitive problems to be related to an increased prevalence of small areas of signal variation within the hippocampus observed on MRI, described as hippocampal sulcal cavities (HSCs; (Maller et al., 2011)). The current study aimed to describe the prevalence of HSCs in patients with treatment-resistant depression (TRD) and healthy controls over a large age-range. Methods: 115 TRD patients and 86 controls underwent MRI brain scanning. Right and left HSCs were rated separately for prevalence and length. Results: HSCs were observed in 73.04%of those with TRD, statistically more prevalent (p=0.001) than amongst controls (51.16%). These findings are consistent with our review (66%prevalence in memory disorders and 47%in healthy controls). Furthermore, HSC presence and length was associated with aging. Limitations: The study was cross-sectional so its implications for aging are tentative. A larger sample scanned longitudinally will allow for more sophisticated statistical methods by which to investigate the relationship between HSCs, aging, and TRD. Conclusions: Although their clinical significance remains uncertain, the results of the current study suggest that HSCs are related with age and those with TRD have more aged brains than their peers. Crown",

keywords = "Aging, Cavity, Depression, Hippocampus, Magnetic resonance imaging, Prevalence",

author = "Maller, {Jerome J} and Chantal Meslin and Chantal Meslin and Thomson, {Richard H.S.} and Melissa Daigle and Barr, {Mera S.} and Daskalakis, {Zafiris J.} and Fitzgerald, {Paul B.}",

year = "2013",

doi = "10.1016/j.jad.2013.02.039",

language = "English",

volume = "150",

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journal = "Journal of Affective Disorders",

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T1 - Hippocampal sulcal cavities in depression and healthy individuals

AU - Maller, Jerome J

AU - Meslin, Chantal

AU - Thomson, Richard H.S.

AU - Daigle, Melissa

AU - Barr, Mera S.

AU - Daskalakis, Zafiris J.

AU - Fitzgerald, Paul B.

PY - 2013

Y1 - 2013

N2 - Background: A literature review suggested age and cognitive problems to be related to an increased prevalence of small areas of signal variation within the hippocampus observed on MRI, described as hippocampal sulcal cavities (HSCs; (Maller et al., 2011)). The current study aimed to describe the prevalence of HSCs in patients with treatment-resistant depression (TRD) and healthy controls over a large age-range. Methods: 115 TRD patients and 86 controls underwent MRI brain scanning. Right and left HSCs were rated separately for prevalence and length. Results: HSCs were observed in 73.04%of those with TRD, statistically more prevalent (p=0.001) than amongst controls (51.16%). These findings are consistent with our review (66%prevalence in memory disorders and 47%in healthy controls). Furthermore, HSC presence and length was associated with aging. Limitations: The study was cross-sectional so its implications for aging are tentative. A larger sample scanned longitudinally will allow for more sophisticated statistical methods by which to investigate the relationship between HSCs, aging, and TRD. Conclusions: Although their clinical significance remains uncertain, the results of the current study suggest that HSCs are related with age and those with TRD have more aged brains than their peers. Crown

AB - Background: A literature review suggested age and cognitive problems to be related to an increased prevalence of small areas of signal variation within the hippocampus observed on MRI, described as hippocampal sulcal cavities (HSCs; (Maller et al., 2011)). The current study aimed to describe the prevalence of HSCs in patients with treatment-resistant depression (TRD) and healthy controls over a large age-range. Methods: 115 TRD patients and 86 controls underwent MRI brain scanning. Right and left HSCs were rated separately for prevalence and length. Results: HSCs were observed in 73.04%of those with TRD, statistically more prevalent (p=0.001) than amongst controls (51.16%). These findings are consistent with our review (66%prevalence in memory disorders and 47%in healthy controls). Furthermore, HSC presence and length was associated with aging. Limitations: The study was cross-sectional so its implications for aging are tentative. A larger sample scanned longitudinally will allow for more sophisticated statistical methods by which to investigate the relationship between HSCs, aging, and TRD. Conclusions: Although their clinical significance remains uncertain, the results of the current study suggest that HSCs are related with age and those with TRD have more aged brains than their peers. Crown

KW - Aging

KW - Cavity

KW - Depression

KW - Hippocampus

KW - Magnetic resonance imaging

KW - Prevalence

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DO - 10.1016/j.jad.2013.02.039

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JO - Journal of Affective Disorders

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ER -

Hippocampal sulcal cavities in depression and healthy individuals

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