Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment

Jerome J Maller; Chantal Meslin; Patrick Chan; Zafiris J. Daskalakis; Richard H.S. Thomson; Kaarin Anstey; Marc Budge; Perminder Singh Sachdev; Paul B. Fitzgerald

doi:10.1016/j.brainres.2010.10.089

Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment

Jerome J Maller, Chantal Meslin, Patrick Chan, Zafiris J. Daskalakis, Richard H.S. Thomson, Kaarin Anstey, Marc Budge, Perminder Singh Sachdev, Paul B. Fitzgerald

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r = 0.64, p = 0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions.

Original language	English
Pages (from-to)	222-230
Journal	Brain Research
Volume	1368
DOIs	https://doi.org/10.1016/j.brainres.2010.10.089
Publication status	Published - 2011

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title = "Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment",

abstract = "While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r = 0.64, p = 0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions.",

author = "Maller, {Jerome J} and Chantal Meslin and Patrick Chan and Daskalakis, {Zafiris J.} and Thomson, {Richard H.S.} and Kaarin Anstey and Marc Budge and Sachdev, {Perminder Singh} and Fitzgerald, {Paul B.}",

year = "2011",

doi = "10.1016/j.brainres.2010.10.089",

language = "English",

volume = "1368",

pages = "222--230",

journal = "Brain Research",

publisher = "Elsevier",

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TY - JOUR

T1 - Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment

AU - Maller, Jerome J

AU - Meslin, Chantal

AU - Chan, Patrick

AU - Daskalakis, Zafiris J.

AU - Thomson, Richard H.S.

AU - Anstey, Kaarin

AU - Budge, Marc

AU - Sachdev, Perminder Singh

AU - Fitzgerald, Paul B.

PY - 2011

Y1 - 2011

N2 - While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r = 0.64, p = 0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions.

AB - While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r = 0.64, p = 0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions.

U2 - 10.1016/j.brainres.2010.10.089

DO - 10.1016/j.brainres.2010.10.089

M3 - Article

VL - 1368

SP - 222

EP - 230

JO - Brain Research

JF - Brain Research

ER -

Hippocampal sulcal cavities: Prevalence, risk factors and relationship to memory impairment

Abstract

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