Hippocampal volumetrics in treatment-resistant depression and schizophrenia: The devil's in De-Tail

Jerome J. Maller; Zafiris J. Daskalakis; Richard H.S. Thomson; Melissa Daigle; Mera S. Barr; Paul B. Fitzgerald

doi:10.1002/hipo.20873

Hippocampal volumetrics in treatment-resistant depression and schizophrenia: The devil's in De-Tail

Jerome J. Maller^*, Zafiris J. Daskalakis, Richard H.S. Thomson, Melissa Daigle, Mera S. Barr, Paul B. Fitzgerald

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Studies of patients with major depressive disorder (MDD) and schizophrenia (SCH) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD, SCH, and healthy subjects, using a strict measurement protocol, to elucidate morphological-specific volumetric differences. Patients with treatment-resistant MDD (N = 182) and treatment-resistant SCH with auditory-verbal hallucinations (N = 52), and healthy controls (N = 76) underwent psychiatric assessments and brain MRI. The findings indicate that (1) MDD and SCH patients have reduced total hippocampal volume which was marked in the tails (more so in patients with MDD), (2) region of interest estimation protocols and sample characteristics may help explain volumetric differences between previous SCH studies.

Original language	English
Pages (from-to)	9-16
Number of pages	8
Journal	Hippocampus
Volume	22
Issue number	1
DOIs	https://doi.org/10.1002/hipo.20873
Publication status	Published - Jan 2012
Externally published	Yes

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title = "Hippocampal volumetrics in treatment-resistant depression and schizophrenia: The devil's in De-Tail",

abstract = "Studies of patients with major depressive disorder (MDD) and schizophrenia (SCH) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD, SCH, and healthy subjects, using a strict measurement protocol, to elucidate morphological-specific volumetric differences. Patients with treatment-resistant MDD (N = 182) and treatment-resistant SCH with auditory-verbal hallucinations (N = 52), and healthy controls (N = 76) underwent psychiatric assessments and brain MRI. The findings indicate that (1) MDD and SCH patients have reduced total hippocampal volume which was marked in the tails (more so in patients with MDD), (2) region of interest estimation protocols and sample characteristics may help explain volumetric differences between previous SCH studies.",

keywords = "Depression, Hippocampus, Magnetic resonance imaging (MRI), Schizophrenia, Volumetrics",

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T2 - The devil's in De-Tail

AU - Maller, Jerome J.

AU - Daskalakis, Zafiris J.

AU - Thomson, Richard H.S.

AU - Daigle, Melissa

AU - Barr, Mera S.

AU - Fitzgerald, Paul B.

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N2 - Studies of patients with major depressive disorder (MDD) and schizophrenia (SCH) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD, SCH, and healthy subjects, using a strict measurement protocol, to elucidate morphological-specific volumetric differences. Patients with treatment-resistant MDD (N = 182) and treatment-resistant SCH with auditory-verbal hallucinations (N = 52), and healthy controls (N = 76) underwent psychiatric assessments and brain MRI. The findings indicate that (1) MDD and SCH patients have reduced total hippocampal volume which was marked in the tails (more so in patients with MDD), (2) region of interest estimation protocols and sample characteristics may help explain volumetric differences between previous SCH studies.

AB - Studies of patients with major depressive disorder (MDD) and schizophrenia (SCH) have revealed reduced hippocampal volumes, but findings have been inconsistent due to sample and measurement differences. The current study sought to measure this structure in a large sample of MDD, SCH, and healthy subjects, using a strict measurement protocol, to elucidate morphological-specific volumetric differences. Patients with treatment-resistant MDD (N = 182) and treatment-resistant SCH with auditory-verbal hallucinations (N = 52), and healthy controls (N = 76) underwent psychiatric assessments and brain MRI. The findings indicate that (1) MDD and SCH patients have reduced total hippocampal volume which was marked in the tails (more so in patients with MDD), (2) region of interest estimation protocols and sample characteristics may help explain volumetric differences between previous SCH studies.

KW - Depression

KW - Hippocampus

KW - Magnetic resonance imaging (MRI)

KW - Schizophrenia

KW - Volumetrics

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Hippocampal volumetrics in treatment-resistant depression and schizophrenia: The devil's in De-Tail

Abstract

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