HIV and T follicular helper cells: A dangerous relationship

Carola G. Vinuesa

doi:10.1172/JCI65175

HIV and T follicular helper cells: A dangerous relationship

Carola G. Vinuesa^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

29 Citations (Scopus)

Abstract

HIV infection leads to progressive destruction of infected CD4 T cells, hypergammaglobulinemia, and loss of memory B cells. Germinal centers, which are key to memory B cell formation and protective antibody responses, are major HIV reservoirs in which the virus replicates within T follicular helper (TFH) cells. In this issue of the JCI, the Koup and Streeck groups report that chronic SIV/HIV infection promotes TFH cell accumulation, which may drive B cell dysregulation. Their discoveries suggest that HIV harnesses TFH cells to evade the antibody response.

Original language	English
Pages (from-to)	3059-3062
Number of pages	4
Journal	Journal of Clinical Investigation
Volume	122
Issue number	9
DOIs	https://doi.org/10.1172/JCI65175
Publication status	Published - 4 Sept 2012

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HIV and T follicular helper cells: A dangerous relationship

Abstract

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