HIV Immunogens: Affinity Is Key

Savit Prabhu; Ian A. Cockburn; Carola G. Vinuesa

doi:10.1016/j.immuni.2018.01.002

HIV Immunogens: Affinity Is Key

Savit Prabhu
, Ian A. Cockburn
, Carola G. Vinuesa^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

2 Citations (Scopus)

Abstract

Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers. Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

Original language	English
Pages (from-to)	11-13
Number of pages	3
Journal	Immunity
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2018.01.002
Publication status	Published - 16 Jan 2018

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10.1016/j.immuni.2018.01.002

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title = "HIV Immunogens: Affinity Is Key",

abstract = "Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers. Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.",

author = "Savit Prabhu and Cockburn, \{Ian A.\} and Vinuesa, \{Carola G.\}",

note = "Publisher Copyright: {\textcopyright} 2018",

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T2 - Affinity Is Key

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AU - Cockburn, Ian A.

AU - Vinuesa, Carola G.

PY - 2018/1/16

Y1 - 2018/1/16

N2 - Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers. Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

AB - Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers. Generation of broadly neutralizing antibodies is a key aim of HIV vaccine design, but the precursor B cells are rare. Abbott et al. (2018) report that high affinity and avidity immunogens are required to promote maturation of low frequency B cells in germinal centers.

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U2 - 10.1016/j.immuni.2018.01.002

DO - 10.1016/j.immuni.2018.01.002

M3 - Short survey

SN - 1074-7613

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SP - 11

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JO - Immunity

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HIV Immunogens: Affinity Is Key

Abstract

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