Host resistance to malaria: Using mouse models to explore the host response

Rhea Longley; Clare Smith; Anny Fortin; Joanne Berghout; Brendan McMorran; Gaétan Burgio; Simon Foote; Philippe Gros

doi:10.1007/s00335-010-9302-6

Host resistance to malaria: Using mouse models to explore the host response

Rhea Longley, Clare Smith, Anny Fortin, Joanne Berghout, Brendan McMorran, Gaétan Burgio, Simon Foote^*, Philippe Gros

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Malaria is a disease that infects over 500 million people, causing at least 1 million deaths every year, with the majority occurring in developing countries. The current antimalarial arsenal is becoming dulled due to the rapid rate of resistance of the parasite. However, in populations living in malaria-endemic regions there are many examples of genetic-based resistance to the severe effects of the parasite Plasmodium. Defining the genetic factors behind host resistance has been an area of great scientific interest over the last few decades; this review summarizes the current knowledge of the genetic loci involved. Perhaps the lessons learned from the natural variation in both the human populations and experimental mouse models of infection may pave the way for novel resistance-proof antimalarials.

Original language	English
Pages (from-to)	32-42
Number of pages	11
Journal	Mammalian Genome
Volume	22
Issue number	1-2
DOIs	https://doi.org/10.1007/s00335-010-9302-6
Publication status	Published - Feb 2011
Externally published	Yes

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AU - Burgio, Gaétan

AU - Foote, Simon

AU - Gros, Philippe

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Host resistance to malaria: Using mouse models to explore the host response

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