How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

Sharon L.H. Ong; Judith A. Whitworth

doi:10.1016/j.ecl.2011.01.010

How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

Sharon L.H. Ong^*, Judith A. Whitworth

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

58 Citations (Scopus)

Abstract

The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.

Original language	English
Pages (from-to)	393-407
Number of pages	15
Journal	Endocrinology and Metabolism Clinics of North America
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2011.01.010
Publication status	Published - Jun 2011

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abstract = "The exact mechanism by which glucocorticoid induces hypertension is unclear. Several mechanisms have been proposed, although there is evidence against the role of sodium and water retention as well as sympathetic nerve activation. This review highlights the role of nitric oxide-redox imbalance and their interactions with arachidonic acid metabolism in glucocorticoid-induced hypertension in humans and experimental animal models.",

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How do glucocorticoids cause hypertension: Role of nitric oxide deficiency, oxidative stress, and eicosanoids

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