How the gene content of human sex chromosomes evolved

Jennifer A.Marshall Graves; Edda Koina; Natasha Sankovic

doi:10.1016/j.gde.2006.04.007

How the gene content of human sex chromosomes evolved

Jennifer A.Marshall Graves^*
, Edda Koina
, Natasha Sankovic

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

54 Citations (Scopus)

Abstract

The X and Y chromosomes of humans and other mammals both have very atypical gene contents. The degenerate Y bears only a handful of genes that are specialized for male sex and reproduction. Now it seems that the X over-represents genes controlling reproductive traits and intelligence. This is hard to explain in terms of function but makes excellent sense in terms of evolution. Comparisons between the gene content of the X and Y in humans, distantly related mammals, and other vertebrates, define the evolutionary past of our sex chromosomes and suggest how special selective forces act on the X and Y.

Original language	English
Pages (from-to)	219-224
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.gde.2006.04.007
Publication status	Published - Jun 2006

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title = "How the gene content of human sex chromosomes evolved",

abstract = "The X and Y chromosomes of humans and other mammals both have very atypical gene contents. The degenerate Y bears only a handful of genes that are specialized for male sex and reproduction. Now it seems that the X over-represents genes controlling reproductive traits and intelligence. This is hard to explain in terms of function but makes excellent sense in terms of evolution. Comparisons between the gene content of the X and Y in humans, distantly related mammals, and other vertebrates, define the evolutionary past of our sex chromosomes and suggest how special selective forces act on the X and Y.",

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AU - Koina, Edda

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N2 - The X and Y chromosomes of humans and other mammals both have very atypical gene contents. The degenerate Y bears only a handful of genes that are specialized for male sex and reproduction. Now it seems that the X over-represents genes controlling reproductive traits and intelligence. This is hard to explain in terms of function but makes excellent sense in terms of evolution. Comparisons between the gene content of the X and Y in humans, distantly related mammals, and other vertebrates, define the evolutionary past of our sex chromosomes and suggest how special selective forces act on the X and Y.

AB - The X and Y chromosomes of humans and other mammals both have very atypical gene contents. The degenerate Y bears only a handful of genes that are specialized for male sex and reproduction. Now it seems that the X over-represents genes controlling reproductive traits and intelligence. This is hard to explain in terms of function but makes excellent sense in terms of evolution. Comparisons between the gene content of the X and Y in humans, distantly related mammals, and other vertebrates, define the evolutionary past of our sex chromosomes and suggest how special selective forces act on the X and Y.

UR - https://www.scopus.com/pages/publications/33646513743

U2 - 10.1016/j.gde.2006.04.007

DO - 10.1016/j.gde.2006.04.007

M3 - Review article

SN - 0959-437X

VL - 16

SP - 219

EP - 224

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

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ER -

How the gene content of human sex chromosomes evolved

Abstract

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