TY - JOUR
T1 - Huntington’s disease
T2 - Neuropsychiatric manifestations of Huntington’s disease
AU - Goh, Anita M.Y.
AU - Wibawa, Pierre
AU - Loi, Samantha M.
AU - Walterfang, Mark
AU - Velakoulis, Dennis
AU - Looi, Jeffrey C.L.
N1 - Publisher Copyright:
© The Royal Australian and New Zealand College of Psychiatrists 2018.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Objectives: Huntington’s disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the person with HD, their carers and family members. This clinical update review focuses on the common neuropsychiatric manifestations in HD, and outlines and evaluates the various neuropsychiatric facets of HD, including the aetiology, symptoms and diagnosis. Conclusions: Neuropsychiatric symptoms can precede the classic motor clinical symptoms of HD (prodromal HD) by decades, and cause significant functional impairment. HD provides key insights and understanding into the organic psychiatric disorders, including contemporary clinical insights into the process of neurodegeneration and manifestation of neuropsychiatric symptoms.
AB - Objectives: Huntington’s disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the person with HD, their carers and family members. This clinical update review focuses on the common neuropsychiatric manifestations in HD, and outlines and evaluates the various neuropsychiatric facets of HD, including the aetiology, symptoms and diagnosis. Conclusions: Neuropsychiatric symptoms can precede the classic motor clinical symptoms of HD (prodromal HD) by decades, and cause significant functional impairment. HD provides key insights and understanding into the organic psychiatric disorders, including contemporary clinical insights into the process of neurodegeneration and manifestation of neuropsychiatric symptoms.
KW - Huntington’s disease
KW - neuropsychiatric manifestations
KW - neuropsychiatry
KW - psychiatry
UR - http://www.scopus.com/inward/record.url?scp=85050189259&partnerID=8YFLogxK
U2 - 10.1177/1039856218791036
DO - 10.1177/1039856218791036
M3 - Article
SN - 1039-8562
VL - 26
SP - 366
EP - 375
JO - Australasian Psychiatry
JF - Australasian Psychiatry
IS - 4
ER -