Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

Michael A. Ernst-Russell; John A. Elix; Christina L.L. Chai; Anthony C. Willis; Nobuo Hamada; Thomas H. Nash

doi:10.1016/S0040-4039(99)01220-4

Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

Michael A. Ernst-Russell, John A. Elix^*, Christina L.L. Chai, Anthony C. Willis, Nobuo Hamada, Thomas H. Nash

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC₅₀ c 0.27 μM), active against the murine P815 mastocytoma cell line.

Original language	English
Pages (from-to)	6321-6324
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	34
DOIs	https://doi.org/10.1016/S0040-4039(99)01220-4
Publication status	Published - 20 Aug 1999

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title = "Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa",

abstract = "Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 μM), active against the murine P815 mastocytoma cell line.",

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AU - Ernst-Russell, Michael A.

AU - Elix, John A.

AU - Chai, Christina L.L.

AU - Willis, Anthony C.

AU - Hamada, Nobuo

AU - Nash, Thomas H.

PY - 1999/8/20

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AB - Hybocarpone (1), a novel pentacyclic naphthazarin-derived dimer has been isolated from mycobiont cultures derived from the lichen Lecanora hybocarpa. The structure of hybocarpone (1) was established on the basis of 1D and 2D NMR spectroscopy. Its relative stereochemistry was predicted with the use of molecular modelling and confirmed by X-ray crystallographic analysis. Hybocarpone (1) was found to be a potent cytotoxin (IC50 c 0.27 μM), active against the murine P815 mastocytoma cell line.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Hybocarpone, a novel cytotoxic naphthazarin derivative from mycobiont cultures of the lichen Lecanora hybocarpa

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