Hydrogen atoms in supramolecular chemistry: a structural perspective. Where are they, and why does it matter?

Amber L. Thompson*, Nicholas G. White*

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    10 Citations (Scopus)

    Abstract

    Hydrogen bonding interactions are ubiquitous across the biochemical and chemical sciences, and are of particular interest to supramolecular chemists. They have been used to assemble hydrogen bonded polymers, cages and frameworks, and are the functional motif in many host–guest systems. Single crystal X-ray diffraction studies are often used as a key support for proposed structures, although this presents challenges as hydrogen atoms interact only weakly with X-rays. In this Tutorial Review, we discuss the information that can be gleaned about hydrogen bonding interactions through crystallographic experiments, key limitations of the data, and emerging techniques to overcome these limitations.

    Original languageEnglish
    Pages (from-to)6254-6269
    Number of pages16
    JournalChemical Society Reviews
    Volume52
    Issue number18
    DOIs
    Publication statusPublished - 21 Aug 2023

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