Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Jean Nicolas Dumez; Jonas Milani; Basile Vuichoud; Aurélien Bornet; Julie Lalande-Martin; Illa Tea; Maxime Yon; Mickaël Maucourt; Catherine Deborde; Annick Moing; Lucio Frydman; Geoffrey Bodenhausen; Sami Jannin; Patrick Giraudeau

doi:10.1039/c5an01203a

Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Jean Nicolas Dumez, Jonas Milani, Basile Vuichoud, Aurélien Bornet, Julie Lalande-Martin, Illa Tea, Maxime Yon, Mickaël Maucourt, Catherine Deborde, Annick Moing, Lucio Frydman, Geoffrey Bodenhausen, Sami Jannin^*, Patrick Giraudeau

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Natural abundance ¹³C NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.

Original language	English
Pages (from-to)	5860-5863
Number of pages	4
Journal	The Analyst
Volume	140
Issue number	17
DOIs	https://doi.org/10.1039/c5an01203a
Publication status	Published - 7 Sept 2015

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AU - Dumez, Jean Nicolas

AU - Milani, Jonas

AU - Vuichoud, Basile

AU - Bornet, Aurélien

AU - Lalande-Martin, Julie

AU - Tea, Illa

AU - Yon, Maxime

AU - Maucourt, Mickaël

AU - Deborde, Catherine

AU - Moing, Annick

AU - Frydman, Lucio

AU - Bodenhausen, Geoffrey

AU - Jannin, Sami

AU - Giraudeau, Patrick

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AB - Natural abundance 13C NMR spectra of biological extracts are recorded in a single scan provided that the samples are hyperpolarized by dissolution dynamic nuclear polarization combined with cross polarization. Heteronuclear 2D correlation spectra of hyperpolarized breast cancer cell extracts can also be obtained in a single scan. Hyperpolarized NMR of extracts opens many perspectives for metabolomics.

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Hyperpolarized NMR of plant and cancer cell extracts at natural abundance

Abstract

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