Abstract
Cardiovascular diseases affect women and men differently: there are sex-dependent differences in the age at
which they become manifest, in the pathophysiologic consequences of various insults, in the relative importance of risk
factors, and in the responses to several treatments (as reviewed recently).1,2 Although many of these differences may
relate to modifications of the lipid profile, as well as differences in the functions of endothelial and/or vascular smooth
muscle cells, it is becoming clear that direct actions within the
heart itself must also be considered. The current review will,
therefore, focus on sex-specific differences in the remodeling
responses of cardiac ventricles to various challenges.
which they become manifest, in the pathophysiologic consequences of various insults, in the relative importance of risk
factors, and in the responses to several treatments (as reviewed recently).1,2 Although many of these differences may
relate to modifications of the lipid profile, as well as differences in the functions of endothelial and/or vascular smooth
muscle cells, it is becoming clear that direct actions within the
heart itself must also be considered. The current review will,
therefore, focus on sex-specific differences in the remodeling
responses of cardiac ventricles to various challenges.
| Original language | English |
|---|---|
| Pages (from-to) | 401-407 |
| Number of pages | 7 |
| Journal | Hypertension |
| Volume | 49 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2007 |