Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

Shakeel Mowlaboccus; Denise Daley; Stanley Pang; Thomas Gottlieb; John Merlino; Graeme R. Nimmo; Narelle George; Tony M. Korman; Richard Streitberg; Jenny Robson; Georgia Peachey; Peter Collignon; Susan Bradbury; Elena Colombi; Joshua P. Ramsay; Benjamin A. Rogers; Geoffrey W. Coombs

doi:10.1016/j.ijantimicag.2020.106121

Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

Shakeel Mowlaboccus^*, Denise Daley, Stanley Pang, Thomas Gottlieb, John Merlino, Graeme R. Nimmo, Narelle George, Tony M. Korman, Richard Streitberg, Jenny Robson, Georgia Peachey, Peter Collignon, Susan Bradbury, Elena Colombi, Joshua P. Ramsay, Benjamin A. Rogers, Geoffrey W. Coombs

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

Original language	English
Article number	106121
Journal	International Journal of Antimicrobial Agents
Volume	56
Issue number	4
DOIs	https://doi.org/10.1016/j.ijantimicag.2020.106121
Publication status	Published - Oct 2020
Externally published	Yes

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Mowlaboccus, S., Daley, D., Pang, S., Gottlieb, T., Merlino, J., Nimmo, G. R., George, N., Korman, T. M., Streitberg, R., Robson, J., Peachey, G., Collignon, P., Bradbury, S., Colombi, E., Ramsay, J. P., Rogers, B. A., & Coombs, G. W. (2020). Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia. International Journal of Antimicrobial Agents, 56(4), Article 106121. https://doi.org/10.1016/j.ijantimicag.2020.106121

@article{eabd6688c6a84c9da9a14b4137885266,

title = "Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia",

abstract = "Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.",

keywords = "Escherichia coli, Fosfomycin resistance, Urinary tract infection, fosA4",

author = "Shakeel Mowlaboccus and Denise Daley and Stanley Pang and Thomas Gottlieb and John Merlino and Nimmo, {Graeme R.} and Narelle George and Korman, {Tony M.} and Richard Streitberg and Jenny Robson and Georgia Peachey and Peter Collignon and Susan Bradbury and Elena Colombi and Ramsay, {Joshua P.} and Rogers, {Benjamin A.} and Coombs, {Geoffrey W.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = oct,

doi = "10.1016/j.ijantimicag.2020.106121",

language = "English",

volume = "56",

journal = "International Journal of Antimicrobial Agents",

issn = "0924-8579",

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Mowlaboccus, S, Daley, D, Pang, S, Gottlieb, T, Merlino, J, Nimmo, GR, George, N, Korman, TM, Streitberg, R, Robson, J, Peachey, G, Collignon, P, Bradbury, S, Colombi, E, Ramsay, JP, Rogers, BA & Coombs, GW 2020, 'Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia', International Journal of Antimicrobial Agents, vol. 56, no. 4, 106121. https://doi.org/10.1016/j.ijantimicag.2020.106121

TY - JOUR

T1 - Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

AU - Mowlaboccus, Shakeel

AU - Daley, Denise

AU - Pang, Stanley

AU - Gottlieb, Thomas

AU - Merlino, John

AU - Nimmo, Graeme R.

AU - George, Narelle

AU - Korman, Tony M.

AU - Streitberg, Richard

AU - Robson, Jenny

AU - Peachey, Georgia

AU - Collignon, Peter

AU - Bradbury, Susan

AU - Colombi, Elena

AU - Ramsay, Joshua P.

AU - Rogers, Benjamin A.

AU - Coombs, Geoffrey W.

PY - 2020/10

Y1 - 2020/10

N2 - Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

AB - Of 1033 Escherichia coli urinary tract infection isolates collected from females >12 years of age in Australia in 2019, only 2 isolates were resistant to fosfomycin with a minimum inhibitory concentration (MIC) of >256 mg/L. Despite having different multilocus sequence types, the two isolates harboured an identical plasmid-encoded fosA4 gene. The fosA4 gene has previously been identified in a single clinical E. coli isolate cultured in Japan in 2014. Each fosfomycin-resistant isolate harboured two conjugative plasmids that possessed an array of genes conferring resistance to aminoglycosides, β-lactams, macrolides, quinolones, sulfonamides and/or trimethoprim.

KW - Escherichia coli

KW - Fosfomycin resistance

KW - Urinary tract infection

KW - fosA4

UR - http://www.scopus.com/inward/record.url?scp=85090067065&partnerID=8YFLogxK

U2 - 10.1016/j.ijantimicag.2020.106121

DO - 10.1016/j.ijantimicag.2020.106121

M3 - Article

SN - 0924-8579

VL - 56

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 4

M1 - 106121

ER -

Identification and characterisation of fosfomycin resistance in Escherichia coli urinary tract infection isolates from Australia

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