Identification and characterization of the Zeta class of glutathione transferases

P. G. Board; G. Chelvanyagam; L. S. Jermiin; A. Blackburn

Identification and characterization of the Zeta class of glutathione transferases

P. G. Board^*, G. Chelvanyagam, L. S. Jermiin, A. Blackburn

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9 exons that extend over 10.9 kb and has been localized to chromosome 14q24.3.

Original language	English
Pages (from-to)	379-384
Number of pages	6
Journal	Clinical Chemistry and Enzymology Communications
Volume	8
Issue number	4-6
Publication status	Published - 1999

Cite this

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abstract = "A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9 exons that extend over 10.9 kb and has been localized to chromosome 14q24.3.",

keywords = "Glutathione transferase zeta",

author = "Board, {P. G.} and G. Chelvanyagam and Jermiin, {L. S.} and A. Blackburn",

year = "1999",

language = "English",

volume = "8",

pages = "379--384",

journal = "Clinical Chemistry and Enzymology Communications",

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T1 - Identification and characterization of the Zeta class of glutathione transferases

AU - Board, P. G.

AU - Chelvanyagam, G.

AU - Jermiin, L. S.

AU - Blackburn, A.

PY - 1999

Y1 - 1999

N2 - A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9 exons that extend over 10.9 kb and has been localized to chromosome 14q24.3.

AB - A new class of glutathione transferase isoenzymes has been identified by sequence data base analysis. The Zeta class isoenzymes occur in a wide range of species including plants, insects and mammals. The human enzyme has been shown to catalyse the glutathione dependent transformation of dichloroacetic acid to glyoxylic acid and the isomerization of maleylacetoacetate to fumarylacetoacetate. The latter reaction is an essential step in the catabolism of tyrosine. The GSTZ1 gene is composed of 9 exons that extend over 10.9 kb and has been localized to chromosome 14q24.3.

KW - Glutathione transferase zeta

UR - http://www.scopus.com/inward/record.url?scp=0033513015&partnerID=8YFLogxK

M3 - Article

SN - 0892-2187

VL - 8

SP - 379

EP - 384

JO - Clinical Chemistry and Enzymology Communications

JF - Clinical Chemistry and Enzymology Communications

IS - 4-6

ER -

Identification and characterization of the Zeta class of glutathione transferases

Abstract

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