IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

Rhea J. Longley; Michael T. White; Jessica Brewster; Zoe S.J. Liu; Caitlin Bourke; Eizo Takashima; Matthias Harbers; Wai Hong Tham; Julie Healer; Chetan E. Chitnis; Wuelton Monteiro; Marcus Lacerda; Jetsumon Sattabongkot; Takafumi Tsuboi; Ivo Mueller

doi:10.1093/ofid/ofab228

IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

Rhea J. Longley, Michael T. White, Jessica Brewster, Zoe S.J. Liu, Caitlin Bourke, Eizo Takashima, Matthias Harbers, Wai Hong Tham, Julie Healer, Chetan E. Chitnis, Wuelton Monteiro, Marcus Lacerda, Jetsumon Sattabongkot, Takafumi Tsuboi, Ivo Mueller^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.

Original language	English
Article number	ofab228
Number of pages	5
Journal	Open Forum Infectious Diseases
Volume	8
Issue number	6
Early online date	22 May 2021
DOIs	https://doi.org/10.1093/ofid/ofab228
Publication status	Published - Jun 2021
Externally published	Yes

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Longley, R. J., White, M. T., Brewster, J., Liu, Z. S. J., Bourke, C., Takashima, E., Harbers, M., Tham, W. H., Healer, J., Chitnis, C. E., Monteiro, W., Lacerda, M., Sattabongkot, J., Tsuboi, T., & Mueller, I. (2021). IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection. Open Forum Infectious Diseases, 8(6), Article ofab228. https://doi.org/10.1093/ofid/ofab228

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title = "IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection",

abstract = "To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.",

keywords = "antibody, IgG, IgM, malaria, Plasmodium vivax, serological exposure markers, serology, surveillance",

author = "Longley, {Rhea J.} and White, {Michael T.} and Jessica Brewster and Liu, {Zoe S.J.} and Caitlin Bourke and Eizo Takashima and Matthias Harbers and Tham, {Wai Hong} and Julie Healer and Chitnis, {Chetan E.} and Wuelton Monteiro and Marcus Lacerda and Jetsumon Sattabongkot and Takafumi Tsuboi and Ivo Mueller",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

year = "2021",

month = jun,

doi = "10.1093/ofid/ofab228",

language = "English",

volume = "8",

journal = "Open Forum Infectious Diseases",

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Longley, RJ, White, MT, Brewster, J, Liu, ZSJ, Bourke, C, Takashima, E, Harbers, M, Tham, WH, Healer, J, Chitnis, CE, Monteiro, W, Lacerda, M, Sattabongkot, J, Tsuboi, T & Mueller, I 2021, 'IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection', Open Forum Infectious Diseases, vol. 8, no. 6, ofab228. https://doi.org/10.1093/ofid/ofab228

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T1 - IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

AU - Longley, Rhea J.

AU - White, Michael T.

AU - Brewster, Jessica

AU - Liu, Zoe S.J.

AU - Bourke, Caitlin

AU - Takashima, Eizo

AU - Harbers, Matthias

AU - Tham, Wai Hong

AU - Healer, Julie

AU - Chitnis, Chetan E.

AU - Monteiro, Wuelton

AU - Lacerda, Marcus

AU - Sattabongkot, Jetsumon

AU - Tsuboi, Takafumi

AU - Mueller, Ivo

PY - 2021/6

Y1 - 2021/6

N2 - To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.

AB - To achieve malaria elimination, new tools are required to explicitly target Plasmodium vivax. Recently, a novel panel of P. vivax proteins were identified and validated as serological markers for detecting recent exposure to P. vivax within the last 9 months. In order to improve the sensitivity and specificity of these markers, immunoglobulin M (IgM) in addition to immunoglobulin G (IgG) antibody responses were compared with a down-selected panel of 20 P. vivax proteins. IgM was tested using archival plasma samples from observational cohort studies conducted in malaria-endemic regions of Thailand and Brazil. IgM responses to these proteins generally had poorer classification performance than IgG.

KW - antibody

KW - IgG

KW - IgM

KW - malaria

KW - Plasmodium vivax

KW - serological exposure markers

KW - serology

KW - surveillance

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DO - 10.1093/ofid/ofab228

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SN - 2328-8957

VL - 8

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 6

M1 - ofab228

ER -

IgG Antibody Responses Are Preferential Compared with IgM for Use as Serological Markers for Detecting Recent Exposure to Plasmodium vivax Infection

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