IL-2 prevents deletion of developing T-regulatory cells in the thymus

Daniel Y. Hu, Rushika C. Wirasinha, Christopher C. Goodnow, Stephen R. Daley*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8-CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.

    Original languageEnglish
    Pages (from-to)1007-1016
    Number of pages10
    JournalCell Death and Differentiation
    Volume24
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2017

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