IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

Charani Ranasinghe*, Shubhanshi Trivedi, Danushka K. Wijesundara, Ronald J. Jackson

*Corresponding author for this work

    Research output: Contribution to journalShort surveypeer-review

    66 Citations (Scopus)

    Abstract

    The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how "alarmin" stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8+ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8+ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.

    Original languageEnglish
    Pages (from-to)437-442
    Number of pages6
    JournalCytokine and Growth Factor Reviews
    Volume25
    Issue number4
    DOIs
    Publication statusPublished - 1 Aug 2014

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