IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

Charani Ranasinghe; Shubhanshi Trivedi; Danushka K. Wijesundara; Ronald J. Jackson

doi:10.1016/j.cytogfr.2014.07.010

IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

Charani Ranasinghe^*
, Shubhanshi Trivedi
, Danushka K. Wijesundara
, Ronald J. Jackson

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

74 Citations (Scopus)

Abstract

The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how "alarmin" stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8⁺ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8⁺ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.

Original language	English
Pages (from-to)	437-442
Number of pages	6
Journal	Cytokine and Growth Factor Reviews
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.cytogfr.2014.07.010
Publication status	Published - 1 Aug 2014

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10.1016/j.cytogfr.2014.07.010

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title = "IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants",

abstract = "The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how {"}alarmin{"} stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8+ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8+ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.",

keywords = "CD8 T cell avidity, IL-13Ra2, IL-4R antagonist, Infection and immunity, Vaccines",

author = "Charani Ranasinghe and Shubhanshi Trivedi and Wijesundara, \{Danushka K.\} and Jackson, \{Ronald J.\}",

note = "Publisher Copyright: {\textcopyright} 2014 Published by Elsevier Ltd.",

year = "2014",

month = aug,

day = "1",

doi = "10.1016/j.cytogfr.2014.07.010",

language = "English",

volume = "25",

pages = "437--442",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier Ltd.",

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TY - JOUR

T1 - IL-4 and IL-13 receptors

T2 - Roles in immunity and powerful vaccine adjuvants

AU - Ranasinghe, Charani

AU - Trivedi, Shubhanshi

AU - Wijesundara, Danushka K.

AU - Jackson, Ronald J.

PY - 2014/8/1

Y1 - 2014/8/1

N2 - The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how "alarmin" stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8+ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8+ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.

AB - The roles of interleukin (IL)-4 and IL-13 during both innate and adaptive Th2 mediated immunity have received considerable scrutiny, however, mechanisms by which these cytokines influence the cellular interactions involved in negatively modulating the development of effective Th1 immunity are poorly characterized. In this article we discuss the recent advances in IL-4/IL-13 biology, mainly (i) role of these cytokines in allergic inflammation, atopic dermatitis, cancer, transplant rejection, bacterial/viral infections, and specifically the therapeutic potential of IL-13Rα2, (ii) insights into how "alarmin" stimulation activate IL-4/IL-13 at the lung mucosae, (iii) how these two cytokines modulate antigen-specific CD8+ T cell quality/avidity in a vaccine route dependent manner and (iv) finally discuss the potential of using transient inhibition of IL-4 and/or IL-13 at the vaccination site as a platform vaccine technology to induce strong sustained high quality CD8+ T cell immunity for protection against many chronic mucosal pathogens such as HIV-1.

KW - CD8 T cell avidity

KW - IL-13Ra2

KW - IL-4R antagonist

KW - Infection and immunity

KW - Vaccines

UR - https://www.scopus.com/pages/publications/84907965970

U2 - 10.1016/j.cytogfr.2014.07.010

DO - 10.1016/j.cytogfr.2014.07.010

M3 - Short survey

SN - 1359-6101

VL - 25

SP - 437

EP - 442

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 4

ER -

IL-4 and IL-13 receptors: Roles in immunity and powerful vaccine adjuvants

Abstract

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