IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

Elizabeth E. Forbes; Katherine Groschwitz; J. Pablo Abonia; Eric B. Brandt; Elizabeth Cohen; Carine Blanchard; Richard Ahrens; Luqman Seidu; Andrew McKenzie; Richard Strait; Fred D. Finkelman; Paul S. Foster; Klaus I. Matthaei; Marc E. Rothenberg; Simon P. Hogan

doi:10.1084/jem.20071046

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

Elizabeth E. Forbes, Katherine Groschwitz, J. Pablo Abonia, Eric B. Brandt, Elizabeth Cohen, Carine Blanchard, Richard Ahrens, Luqman Seidu, Andrew McKenzie, Richard Strait, Fred D. Finkelman, Paul S. Foster, Klaus I. Matthaei, Marc E. Rothenberg, Simon P. Hogan

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Abstract

Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy. JEM

Original language	English
Pages (from-to)	897-913
Number of pages	17
Journal	Journal of Experimental Medicine
Volume	205
Issue number	4
DOIs	https://doi.org/10.1084/jem.20071046
Publication status	Published - 14 Apr 2008

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Forbes, E. E., Groschwitz, K., Abonia, J. P., Brandt, E. B., Cohen, E., Blanchard, C., Ahrens, R., Seidu, L., McKenzie, A., Strait, R., Finkelman, F. D., Foster, P. S., Matthaei, K. I., Rothenberg, M. E., & Hogan, S. P. (2008). IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. Journal of Experimental Medicine, 205(4), 897-913. https://doi.org/10.1084/jem.20071046

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title = "IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity",

abstract = "Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy. JEM",

author = "Forbes, {Elizabeth E.} and Katherine Groschwitz and Abonia, {J. Pablo} and Brandt, {Eric B.} and Elizabeth Cohen and Carine Blanchard and Richard Ahrens and Luqman Seidu and Andrew McKenzie and Richard Strait and Finkelman, {Fred D.} and Foster, {Paul S.} and Matthaei, {Klaus I.} and Rothenberg, {Marc E.} and Hogan, {Simon P.}",

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Forbes, EE, Groschwitz, K, Abonia, JP, Brandt, EB, Cohen, E, Blanchard, C, Ahrens, R, Seidu, L, McKenzie, A, Strait, R, Finkelman, FD, Foster, PS, Matthaei, KI, Rothenberg, ME & Hogan, SP 2008, 'IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity', Journal of Experimental Medicine, vol. 205, no. 4, pp. 897-913. https://doi.org/10.1084/jem.20071046

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T1 - IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

AU - Forbes, Elizabeth E.

AU - Groschwitz, Katherine

AU - Abonia, J. Pablo

AU - Brandt, Eric B.

AU - Cohen, Elizabeth

AU - Blanchard, Carine

AU - Ahrens, Richard

AU - Seidu, Luqman

AU - McKenzie, Andrew

AU - Strait, Richard

AU - Finkelman, Fred D.

AU - Foster, Paul S.

AU - Matthaei, Klaus I.

AU - Rothenberg, Marc E.

AU - Hogan, Simon P.

PY - 2008/4/14

Y1 - 2008/4/14

N2 - Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy. JEM

AB - Previous mouse and clinical studies demonstrate a link between Th2 intestinal inflammation and induction of the effector phase of food allergy. However, the mechanism by which sensitization and mast cell responses occurs is largely unknown. We demonstrate that interleukin (IL)-9 has an important role in this process. IL-9-deficient mice fail to develop experimental oral antigen-induced intestinal anaphylaxis, and intestinal IL-9 overexpression induces an intestinal anaphylaxis phenotype (intestinal mastocytosis, intestinal permeability, and intravascular leakage). In addition, intestinal IL-9 overexpression predisposes to oral antigen sensitization, which requires mast cells and increased intestinal permeability. These observations demonstrate a central role for IL-9 and mast cells in experimental intestinal permeability in oral antigen sensitization and suggest that IL-9-mediated mast cell responses have an important role in food allergy. JEM

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U2 - 10.1084/jem.20071046

DO - 10.1084/jem.20071046

M3 - Article

SN - 0022-1007

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SP - 897

EP - 913

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

IS - 4

ER -

IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity

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