Imaging Cells in Living Animals with Two Photon In-Vivo Abberation-Free Endomicroscopy

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Endomicroscopes have proven to be a powerful tool in deep tissue imaging, thus enabling non-invasive high resolution longitudinal optical imaging of disease model in small animals [(Kim, Lee et al. 2012)]. Existing components includes fiber bundle, miniature compound microlens and graded index (GRIN) lens. The design flexibility of GRIN lens microendoscope proved to be of an advantage when imaging a variety of visceral organs [(Kim, Lee et al. 2012)]. However, large spatial variations in the aberrations associated with GRIN lens over the full field of view impede high resolution at the extreme points in the field and depth of view [(Lee and Yun 2011)]. In this paper, we introduced a sensorless adaptive optics approach that minimizes the aberrations at these selected positions.
    Original languageEnglish
    Title of host publicationAustralia
    Place of PublicationAustralia
    PublisherEngineers Australia
    EditionNot reviewed
    Publication statusPublished - 2014
    EventAustralian Biomedical Engineering Conference ABEC 2014 - Canberra, Australia, Australia
    Duration: 1 Jan 2014 → …

    Conference

    ConferenceAustralian Biomedical Engineering Conference ABEC 2014
    Country/TerritoryAustralia
    Period1/01/14 → …
    OtherFri Aug 01 00:00:00 AEST 2014

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