Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

Robert Booy; Peter Richmond; Terry Nolan; Jodie McVernon; Helen Marshall; Michael Nissen; Graham Reynolds; John B. Ziegler; Leon Heron; Stephen Lambert; Magalie Caubet; Narcisa Mesaros; Dominique Boutriau

doi:10.1097/INF.0b013e31820013d2

Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

Robert Booy^*, Peter Richmond, Terry Nolan, Jodie McVernon, Helen Marshall, Michael Nissen, Graham Reynolds, John B. Ziegler, Leon Heron, Stephen Lambert, Magalie Caubet, Narcisa Mesaros, Dominique Boutriau

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenCCRM₁₉₇ vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥8 or anti-PRP concentration ≥0.15 μg/mL. After 12 months, rSBA titer ≥8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥0.15 μg/mL persisted in 98.8% and 100% of children, respectively.

Original language	English
Pages (from-to)	340-342
Number of pages	3
Journal	Pediatric Infectious Disease Journal
Volume	30
Issue number	4
DOIs	https://doi.org/10.1097/INF.0b013e31820013d2
Publication status	Published - Apr 2011
Externally published	Yes

Access to Document

10.1097/INF.0b013e31820013d2

Fingerprint

Dive into the research topics of 'Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age'. Together they form a unique fingerprint.

Cite this

Booy, R., Richmond, P., Nolan, T., McVernon, J., Marshall, H., Nissen, M., Reynolds, G., Ziegler, J. B., Heron, L., Lambert, S., Caubet, M., Mesaros, N., & Boutriau, D. (2011). Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. Pediatric Infectious Disease Journal, 30(4), 340-342. https://doi.org/10.1097/INF.0b013e31820013d2

@article{be8399bcb9f74726b717d436430ed438,

title = "Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age",

abstract = "Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenCCRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥8 or anti-PRP concentration ≥0.15 μg/mL. After 12 months, rSBA titer ≥8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥0.15 μg/mL persisted in 98.8% and 100% of children, respectively.",

keywords = "Antibody persistence, Haemophilus influenzae type b, Neisseria meningitidis serogroup C, Toddlers",

author = "Robert Booy and Peter Richmond and Terry Nolan and Jodie McVernon and Helen Marshall and Michael Nissen and Graham Reynolds and Ziegler, {John B.} and Leon Heron and Stephen Lambert and Magalie Caubet and Narcisa Mesaros and Dominique Boutriau",

year = "2011",

month = apr,

doi = "10.1097/INF.0b013e31820013d2",

language = "English",

volume = "30",

pages = "340--342",

journal = "Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "4",

}

Booy, R, Richmond, P, Nolan, T, McVernon, J, Marshall, H, Nissen, M, Reynolds, G, Ziegler, JB, Heron, L, Lambert, S, Caubet, M, Mesaros, N & Boutriau, D 2011, 'Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age', Pediatric Infectious Disease Journal, vol. 30, no. 4, pp. 340-342. https://doi.org/10.1097/INF.0b013e31820013d2

Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. / Booy, Robert; Richmond, Peter; Nolan, Terry et al.
In: Pediatric Infectious Disease Journal, Vol. 30, No. 4, 04.2011, p. 340-342.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

AU - Booy, Robert

AU - Richmond, Peter

AU - Nolan, Terry

AU - McVernon, Jodie

AU - Marshall, Helen

AU - Nissen, Michael

AU - Reynolds, Graham

AU - Ziegler, John B.

AU - Heron, Leon

AU - Lambert, Stephen

AU - Caubet, Magalie

AU - Mesaros, Narcisa

AU - Boutriau, Dominique

PY - 2011/4

Y1 - 2011/4

N2 - Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenCCRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥8 or anti-PRP concentration ≥0.15 μg/mL. After 12 months, rSBA titer ≥8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥0.15 μg/mL persisted in 98.8% and 100% of children, respectively.

AB - Hib-primed but MenC-naive toddlers (N = 433) were randomized to receive 1 dose of Hib-MenC-TT or separate Hib-TT and MenCCRM197 vaccines. One month later, noninferiority was demonstrated for serum bactericidal anti-MenC antibodies (rSBA) and Hib antipolyribosylribitol phosphate (PRP) antibodies; >99% in both groups had rSBA titer ≥8 or anti-PRP concentration ≥0.15 μg/mL. After 12 months, rSBA titer ≥8 persisted in 86.7% and 76.4%, and anti-PRP concentration ≥0.15 μg/mL persisted in 98.8% and 100% of children, respectively.

KW - Antibody persistence

KW - Haemophilus influenzae type b

KW - Neisseria meningitidis serogroup C

KW - Toddlers

UR - http://www.scopus.com/inward/record.url?scp=79954690914&partnerID=8YFLogxK

U2 - 10.1097/INF.0b013e31820013d2

DO - 10.1097/INF.0b013e31820013d2

M3 - Article

SN - 0891-3668

VL - 30

SP - 340

EP - 342

JO - Pediatric Infectious Disease Journal

JF - Pediatric Infectious Disease Journal

IS - 4

ER -

Booy R, Richmond P, Nolan T, McVernon J, Marshall H, Nissen M et al. Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age. Pediatric Infectious Disease Journal. 2011 Apr;30(4):340-342. doi: 10.1097/INF.0b013e31820013d2

Immediate and longer term immunogenicity of a single dose of the combined Haemophilus influenzae type b-Neisseria meningitidis serogroup c-tetanus toxoid conjugate vaccine in primed toddlers 12 to 18 months of age

Abstract

Access to Document

Other files and links

Fingerprint

Cite this