Immunohistochemistry of omega class glutathione S-transferase in human tissues

Z. L. Yin; J. E. Dahlstrom; D. G. Le Couteur; P. G. Board

doi:10.1177/002215540104900806

Immunohistochemistry of omega class glutathione S-transferase in human tissues

Z. L. Yin, J. E. Dahlstrom, D. G. Le Couteur, P. G. Board^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Citations (Scopus)

Abstract

Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs.

Original language	English
Pages (from-to)	983-987
Number of pages	5
Journal	Journal of Histochemistry and Cytochemistry
Volume	49
Issue number	8
DOIs	https://doi.org/10.1177/002215540104900806
Publication status	Published - 2001

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title = "Immunohistochemistry of omega class glutathione S-transferase in human tissues",

abstract = "Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs.",

keywords = "GSTO, Glutathione transferase, Immunohistochemistry, Omega",

author = "Yin, {Z. L.} and Dahlstrom, {J. E.} and {Le Couteur}, {D. G.} and Board, {P. G.}",

year = "2001",

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AU - Yin, Z. L.

AU - Dahlstrom, J. E.

AU - Le Couteur, D. G.

AU - Board, P. G.

PY - 2001

Y1 - 2001

N2 - Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs.

AB - Omega class glutathione transferase (GSTO) has been recently described in a number of mammalian species. We used immunohistochemistry to determine the cellular and tissue distribution of GSTO1-1 in humans. Expression of GSTO1-1 was abundant in a wide range of normal tissues, particularly liver, macrophages, glial cells, and endocrine cells. We also found nuclear staining in several types of cells, including glial cells, myoepithelial cells of the breast, neuroendocrine cells of colon, fetal myocytes, hepatocytes, biliary epithelium, ductal epithelium of the pancreas, Hoffbauer cells of the placenta, and follicular and C-cells of the thyroid. These observations and the known activity of GSTO1-1 suggest biological functions that are not shared with other GSTs.

KW - GSTO

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DO - 10.1177/002215540104900806

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JF - Journal of Histochemistry and Cytochemistry

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Immunohistochemistry of omega class glutathione S-transferase in human tissues

Abstract

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