Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Catherine J. Lees; Vasso Apostolopoulos; Bruce Acres; Ian Ramshaw; Alistair Ramsay; Chin Swee Ong; Ian F.C. McKenzie

doi:10.1016/S0264-410X(00)00065-7

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Catherine J. Lees, Vasso Apostolopoulos, Bruce Acres, Ian Ramshaw, Alistair Ramsay, Chin Swee Ong, Ian F.C. McKenzie^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8⁺ cytotoxic T cells. We now demonstrate that in MUC1/HLA- A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	158-162
Number of pages	5
Journal	Vaccine
Volume	19
Issue number	2-3
DOIs	https://doi.org/10.1016/S0264-410X(00)00065-7
Publication status	Published - 15 Sept 2000

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title = "Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice",

abstract = "Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA- A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice. (C) 2000 Elsevier Science Ltd.",

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AU - Lees, Catherine J.

AU - Apostolopoulos, Vasso

AU - Acres, Bruce

AU - Ramshaw, Ian

AU - Ramsay, Alistair

AU - Ong, Chin Swee

AU - McKenzie, Ian F.C.

PY - 2000/9/15

Y1 - 2000/9/15

N2 - Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA- A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice. (C) 2000 Elsevier Science Ltd.

AB - Mice immunised with oxidised mannan-MUC1 fusion protein (M-FP) develop MHC restricted CD8+ cytotoxic T cells. We now demonstrate that in MUC1/HLA- A2 transgenic mice, IL-12 gives enhanced CTL, CTLp and tumor protection. CTLp in MUC1 transgenic mice with M-FP were 1/55,000, and with IL-12, this increased to 1/19,000, with improved tumor protection. Thus, IL-12 is important for effective CTL responses to MUC1 in transgenic mice. (C) 2000 Elsevier Science Ltd.

KW - Cytokines

KW - MUC1

KW - Transgenic

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VL - 19

SP - 158

EP - 162

JO - Vaccine

JF - Vaccine

IS - 2-3

ER -

Immunotherapy with mannan-MUC1 and IL-12 in MUC1 transgenic mice

Abstract

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