Abstract
Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only ( N= 20), MDD ( N= 17), and TBI-MDD ( N= 15) compared to healthy controls ( N= 31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.
Original language | English |
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Pages (from-to) | 115-124 |
Number of pages | 10 |
Journal | Biological Psychology |
Volume | 99 |
Issue number | 1 |
DOIs | |
Publication status | Published - May 2014 |
Externally published | Yes |