TY - JOUR
T1 - Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone
AU - Lantum, Hoffman B.M.
AU - Board, Philip G.
AU - Anders, M. W.
PY - 2001
Y1 - 2001
N2 - Glutathione transferase zeta (GSTZ1-1), 1 which is identical to maleylacetoacetate isomerase (EC 5.2.1.2) 2 is the penultimate enzyme in the tyrosine degradation pathway. GSTZ1-1 catalyzes the glutathione (GSH)-dependent cis-trans isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA). Maleylacetone (MA), a decarboxylation product of MAA, is a substrate for the Vibrio 01 isomerase and is converted to fumarylacetone (FA). 3 No other endogenous role for GSTZ1-1 is known, but GSTZ1-1 also catalyzes the GSH-dependent biotransformation of a range of a-haloacids, such as dichloroacetic acid (DCA) and chlorofluoroacetic acid (CFA) 4
AB - Glutathione transferase zeta (GSTZ1-1), 1 which is identical to maleylacetoacetate isomerase (EC 5.2.1.2) 2 is the penultimate enzyme in the tyrosine degradation pathway. GSTZ1-1 catalyzes the glutathione (GSH)-dependent cis-trans isomerization of maleylacetoacetate (MAA) to fumarylacetoacetate (FAA). Maleylacetone (MA), a decarboxylation product of MAA, is a substrate for the Vibrio 01 isomerase and is converted to fumarylacetone (FA). 3 No other endogenous role for GSTZ1-1 is known, but GSTZ1-1 also catalyzes the GSH-dependent biotransformation of a range of a-haloacids, such as dichloroacetic acid (DCA) and chlorofluoroacetic acid (CFA) 4
UR - http://www.scopus.com/inward/record.url?scp=0035697707&partnerID=8YFLogxK
U2 - 10.1007/978-1-4615-0667-6_54
DO - 10.1007/978-1-4615-0667-6_54
M3 - Article
SN - 0065-2598
VL - 500
SP - 339
EP - 342
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -