Inflammation associates with impaired small arterial elasticity early in HIV disease

doi:10.1093/ofid/ofy117

Inflammation associates with impaired small arterial elasticity early in HIV disease

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7 Citations (Scopus)

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	6
DOIs	https://doi.org/10.1093/ofid/ofy117
Publication status	Published - 1 Jun 2018
Externally published	Yes

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10.1093/ofid/ofy117

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@article{c4e69844deac4544883b2a01116a2d86,

title = "Inflammation associates with impaired small arterial elasticity early in HIV disease",

abstract = "We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-na{\"i}ve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.",

keywords = "Arterial elasticity, Cardiovascular disease, HIV infection, Systemic inflammation, Vascular dysfunction",

author = "Peterson, \{Tess E.\} and Hullsiek, \{Katherine Huppler\} and Engen, \{Nicole Wyman\} and Nagalingeswaran Kumarasamy and Lebech, \{Anne Mette\} and Angelike Liappis and Antonios Papadopoulos and Polizzotto, \{Mark N.\} and Schreiner, \{Pamela J.\} and Daniel Duprez and Baker, \{Jason V.\}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2018",

month = jun,

day = "1",

doi = "10.1093/ofid/ofy117",

language = "English",

volume = "5",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press ",

number = "6",

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TY - JOUR

T1 - Inflammation associates with impaired small arterial elasticity early in HIV disease

AU - Peterson, Tess E.

AU - Hullsiek, Katherine Huppler

AU - Engen, Nicole Wyman

AU - Kumarasamy, Nagalingeswaran

AU - Lebech, Anne Mette

AU - Liappis, Angelike

AU - Papadopoulos, Antonios

AU - Polizzotto, Mark N.

AU - Schreiner, Pamela J.

AU - Duprez, Daniel

AU - Baker, Jason V.

N1 - Publisher Copyright: © The Author(s) 2018.

PY - 2018/6/1

Y1 - 2018/6/1

N2 - We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

AB - We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

KW - Arterial elasticity

KW - Cardiovascular disease

KW - HIV infection

KW - Systemic inflammation

KW - Vascular dysfunction

UR - https://www.scopus.com/pages/publications/85065556243

U2 - 10.1093/ofid/ofy117

DO - 10.1093/ofid/ofy117

M3 - Article

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 6

ER -

Inflammation associates with impaired small arterial elasticity early in HIV disease

Abstract

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