Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative

Kevin J. Saliba*, Sanjeev Krishna, Kiaran Kirk

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    36 Citations (Scopus)

    Abstract

    An O-3-hexose derivative, shown previously to inhibit a malaria parasite hexose transporter expressed in Xenopus oocytes as well as to suppress the multiplication of parasites, both in vitro and in vivo, was shown here to block the uptake of hexose sugars into isolated blood-stage parasites. This led to a decline in ATP levels and the loss of intracellular pH control. The results are consistent with those obtained with the cloned transporter. They support the notion that the transporter mediates uptake of glucose into the intraerythrocytic parasite and provide further support for the view that it is a suitable antimalarial drug target.

    Original languageEnglish
    Pages (from-to)93-96
    Number of pages4
    JournalFEBS Letters
    Volume570
    Issue number1-3
    DOIs
    Publication statusPublished - 16 Jul 2004

    Fingerprint

    Dive into the research topics of 'Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative'. Together they form a unique fingerprint.

    Cite this