TY - JOUR
T1 - Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides
AU - Adams, Yvonne
AU - Freeman, Craig
AU - Schwartz-Albiez, Reinhard
AU - Ferro, Vito
AU - Parish, Christopher R.
AU - Andrews, Katherine T.
PY - 2006/8
Y1 - 2006/8
N2 - A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.
AB - A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.
UR - http://www.scopus.com/inward/record.url?scp=33746914763&partnerID=8YFLogxK
U2 - 10.1128/AAC.00313-06
DO - 10.1128/AAC.00313-06
M3 - Article
SN - 0066-4804
VL - 50
SP - 2850
EP - 2852
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 8
ER -