Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

Yvonne Adams; Craig Freeman; Reinhard Schwartz-Albiez; Vito Ferro; Christopher R. Parish; Katherine T. Andrews

doi:10.1128/AAC.00313-06

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

Yvonne Adams, Craig Freeman, Reinhard Schwartz-Albiez, Vito Ferro, Christopher R. Parish, Katherine T. Andrews^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.

Original language	English
Pages (from-to)	2850-2852
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	50
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00313-06
Publication status	Published - Aug 2006

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10.1128/AAC.00313-06

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title = "Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides",

abstract = "A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50\% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.",

author = "Yvonne Adams and Craig Freeman and Reinhard Schwartz-Albiez and Vito Ferro and Parish, \{Christopher R.\} and Andrews, \{Katherine T.\}",

year = "2006",

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language = "English",

volume = "50",

pages = "2850--2852",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides. / Adams, Yvonne; Freeman, Craig; Schwartz-Albiez, Reinhard et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 8, 08.2006, p. 2850-2852.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

AU - Adams, Yvonne

AU - Freeman, Craig

AU - Schwartz-Albiez, Reinhard

AU - Ferro, Vito

AU - Parish, Christopher R.

AU - Andrews, Katherine T.

PY - 2006/8

Y1 - 2006/8

N2 - A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.

AB - A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA). The heparan sulfate mimetic PI-88, currently undergoing phase II anticancer trials, displayed the greatest in vitro antimalarial activity against Plasmodium falciparum (50% inhibitory concentration of 7.4 μM) and demonstrated modest adhesion inhibition to cell surface CSA.

UR - https://www.scopus.com/pages/publications/33746914763

U2 - 10.1128/AAC.00313-06

DO - 10.1128/AAC.00313-06

M3 - Article

SN - 0066-4804

VL - 50

SP - 2850

EP - 2852

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides

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